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Small intestine endoscopy detected a dark purpuric protruding tumor of the jejunum and its biopsy specimen brought a definitive diagnosis of primary jejunal epithelioid angiosarcoma from positive staining of AE1\/AE3, CD31, and erythroblast transformation specific related gene in immunohistochemical studies. The patient underwent surgical resection with adjuvant chemotherapy but died of progression of metastases 7 months after the diagnosis. Epithelioid angiosarcoma of the gastrointestinal tract is an extremely rare malignancy with poor prognosis and it is challenging to distinguish from undifferentiated carcinoma or melanoma. Immunohistochemistry is necessary for a definitive diagnosis. Sufficient biopsy specimen may aid a prompt diagnosis of this disease of the small intestine, which may present as obscure gastrointestinal bleeding.<\/jats:p>","DOI":"10.1002\/deo2.24","type":"journal-article","created":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T08:38:51Z","timestamp":1629621531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Successful endoscopic diagnosis of angiosarcoma of the small intestine: A case report"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1016-9817","authenticated-orcid":false,"given":"Koichi","family":"Tamura","sequence":"first","affiliation":[{"name":"Second Department of Surgery School of Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Second Department of Surgery School of Medicine 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