{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:10:19Z","timestamp":1779894619739,"version":"3.53.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T00:00:00Z","timestamp":1629590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Self\u2010assembling peptides (TDMs) comprise synthetic amphipathic peptides that immediately react to changes in pH and\/or inorganic salts to transform into a gelatinous state. The first generation of these peptides (TDM\u2010621) is currently used as a hemostatic agent in Europe. However, TDM\u2010621 exhibits slow gel\u2010formation and low retention capabilities on tissue surfaces. The second generation (TDM\u2010623) was therefore developed to encourage faster gel\u2010formation and better tissue\u2010sealing capabilities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to verify the efficacy of TDM\u2010623 in terms of its hemostatic effect in endoscopic surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Evaluation of the hemostatic effect in endoscopic surgery (animal study) was performed using eight porcine in spine position. Following systemic heparinization, we established a \u201cbleeding model\u201d by endoscopic grasping forceps on the anterior walls of the stomach and duodenum. In the hemostasis method, an endoscope with a distal hood was brought into contact with the bleeding point, and 1 ml TDM\u2010623 was applied to the wound. After TDM\u2010623 gelation, the endoscope was removed, and the acute hemostatic effect (after 2 min) was confirmed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>In the endoscopic bleeding model, 17 of the 23 cases (74%) showed complete hemostatic effects on the anterior wall of the stomach, and 18 of the 20 cases (80%) on the anterior wall of the duodenum, respectively. None of the applied gels were displaced from the anterior walls of the stomach and duodenum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The new self\u2010assembling peptide (TDM\u2010623) showed high hemostatic effects. TDM\u2010623 had potential usefulness for upper gastrointestinal endoscopic surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/deo2.25","type":"journal-article","created":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T08:36:21Z","timestamp":1629621381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Endoscopic application of novel, infection\u2010free, advanced hemostatic material: Its usefulness to upper gastrointestinal oozing"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4017-1272","authenticated-orcid":false,"given":"Yuto","family":"Kubo","sequence":"first","affiliation":[{"name":"Department of Next Generation Endoscopic Intervention (Project ENGINE) Graduate School of Medicine Center of Medical Innovation and Translational Research Osaka University  Osaka Japan"},{"name":"Department of Gastroenterological Surgery Graduate School of Medicine Osaka University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"3\u2010D Matrix Ltd.  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