{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:32:42Z","timestamp":1755225162795,"version":"3.43.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K17398"],"award-info":[{"award-number":["22K17398"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cronkhite\u2010Canada syndrome (CCS) is a rare disease characterized by gastrointestinal polyposis, skin pigmentation, alopecia, and abnormal nailfolds. Although colorectal cancer has been reported in patients with CCS, reports are limited regarding the effectiveness of the usage of image\u2010enhanced endoscopy in CCS lesions. Here, we report a case of CCS in which narrow\u2010band imaging (NBI) magnifying endoscopy was applied to detect an adenomatous component in multiple hamartomatous polyps. A 79\u2010year\u2010old female complained of taste disorder, anorexia, and weight loss over several months. Endoscopic examination revealed multiple reddened polyps in the stomach and colon, leading to a diagnosis of CCS. Narrow\u2010band imaging magnification showed sparse and dilated round pits on the CCS polyps. Furthermore, 12 out of the numerous colorectal CCS polyps had a coexisting light reddish elevated component with a regular distribution of microvessels and a regular reticular pattern. This pattern satisfied the criteria for Type 2A of the Japan Narrow\u2010band\u2010imaging Expert Team classification, indicating adenoma. After resection, these twelve polyps were subject to pathological analysis, which confirmed they were all hamartomatous polyps with low\u2010grade adenoma on the superficial layer. Immunohistochemical analysis revealed a significant increase in the Ki\u201067 index and p53 staining only in the adenomatous lesions. We conclude that narrow\u2010band imaging magnifying endoscopy would be useful in differentiating adenoma from CCS\u2010related polyps, which thereby facilitates early detection and treatment of precancerous lesions.<\/jats:p>","DOI":"10.1002\/deo2.257","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T02:43:00Z","timestamp":1686883380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Narrow\u2010band imaging with magnification for the diagnosis of colorectal adenoma in a patient with Cronkhite\u2010Canada syndrome"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1802-9437","authenticated-orcid":false,"given":"Hitoshi","family":"Fukase","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kumamoto University Hospital Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munenori","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kumamoto University Hospital Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kumamoto University Hospital Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kumamoto University Hospital Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Gushima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kumamoto University Hospital Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Naoe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kumamoto University Hospital Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rin","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Cell Pathology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Komohara","sequence":"additional","affiliation":[{"name":"Department of Cell Pathology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kumamoto University Hospital Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/856873"},{"key":"e_1_2_6_3_1","first-page":"3","article-title":"Cronkhite\u2010Canada syndrome: Epidemiological study of 110 cases reported in Japan","volume":"64","author":"Goto A","year":"1995","journal-title":"Nihon geka hokan"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198209000-00002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-015-1107-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-19-0652-7_1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2021.20667"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2008.05.002"},{"key":"e_1_2_6_9_1","first-page":"197","article-title":"A case of Cronkhite\u2010Canada syndrome and a review of gastrointestinal polyposis syndromes","volume":"8","author":"Seshadri D","year":"2012","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12644"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.15369\/sujms.22.69"}],"container-title":["DEN 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