{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:32:45Z","timestamp":1755225165714,"version":"3.43.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dabigatran is a useful and widely used drug for stroke prevention in patients with atrial fibrillation. However, it has been reported to cause esophagitis. Herein, we report\u00a0the case of a\u00a077\u2010year\u2010old man with dabigatran\u2010induced esophagitis with blue pigmentation, which is known to be a rare adverse effect. The patient\u00a0presented to our hospital with a tightness\u00a0of the\u00a0chest and anorexia.\u00a0Computed tomography revealed a thickening of the entire esophageal wall,\u00a0with an upper esophageal predominance. Esophagogastroduodenoscopy was performed, which\u00a0showed that the cervical and upper thoracic esophagus had blue pigmentation\u00a0with\u00a0edematous changes, partial narrowing, and longitudinal sloping. We replaced\u00a0dabigatran with\u00a0edoxaban, a similar anticoagulation\u00a0medication. The patient was closely monitored for\u00a01\u00a0month after switching\u00a0to\u00a0edoxaban. The follow\u2010up esophagogastroduodenoscopy showed\u00a0marked\u00a0improvements, revealing\u00a0resolution of the bluish discoloration and edematous changes, and the patient's complaints\u00a0regarding the tightness of the\u00a0chest and anorexia\u00a0were\u00a0also\u00a0resolved. It is important\u00a0to recognize that such side effects can occur with dabigatran, a drug that is frequently used in daily practice.\u00a0Considering the fact that strong edematous changes can cause indigo\u00a0carmine pigmentation associated with dabigatran stagnation, we recommend switching to another anticoagulant if esophagitis occurs during dabigatran administration.<\/jats:p>","DOI":"10.1002\/deo2.271","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T01:39:19Z","timestamp":1689644359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dabigatran\u2010induced esophagitis with full circumferential blue pigmentation"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6811-1415","authenticated-orcid":false,"given":"Tomonori","family":"Araki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Graduate School of Biomedical Sciences, Nagasaki University Nagasaki Japan"},{"name":"Medical Education Development Center Nagasaki University Hospital Nagasaki Japan"},{"name":"Nagasaki Memorial Hospital Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Graduate School of Biomedical Sciences, Nagasaki University Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Graduate School of Biomedical Sciences, Nagasaki University Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Graduate School of Biomedical Sciences, Nagasaki University Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Imamura","sequence":"additional","affiliation":[{"name":"Medical Education Development Center Nagasaki University Hospital Nagasaki Japan"},{"name":"Nagasaki Memorial Hospital Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Koide","sequence":"additional","affiliation":[{"name":"Medical Education Development Center Nagasaki University Hospital Nagasaki Japan"},{"name":"Nagasaki Memorial Hospital Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisayuki","family":"Hamada","sequence":"additional","affiliation":[{"name":"Medical Education Development Center Nagasaki University Hospital Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Graduate School of Biomedical Sciences, Nagasaki University Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.08.031"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13024"},{"key":"e_1_2_6_5_1","first-page":"1096","article-title":"Two cases of dabigatran\u2010induced esophageal ulcer indicating the usefulness of drug administration guidance","volume":"111","author":"Izumikawa K","year":"2014","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000071"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.6606"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2009.00972.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310907"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.10.021"}],"container-title":["DEN 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