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This paper reviews advancements in endoscopic ultrasound\u2010guided fine needle aspiration and biopsy techniques and devices, emphasizing the importance of handling specimens for diagnostic accuracy. Innovations of fine needle biopsy needles with features like side holes and Franseen shapes have enhanced histological sampling capabilities. Techniques for specimen handling, including rapid on\u2010site evaluation and macroscopic on\u2010site evaluation, play pivotal roles in assessing sample adequacy, thereby influencing diagnostic outcomes. The utility of artificial intelligence in augmenting rapid on\u2010site evaluation and macroscopic on\u2010site evaluation, although still in experimental stages, presents a promising avenue for improving procedural efficiency and diagnostic precision. The choice of specimen handling technique is dependent on various factors including endoscopist preference, procedure objectives, and available resources, underscoring the need for a comprehensive understanding of each method's characteristics to optimize diagnostic efficacy and procedural safety.<\/jats:p>","DOI":"10.1002\/deo2.350","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T02:42:53Z","timestamp":1710556973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Advances and efficacy in specimen handling for endoscopic ultrasound\u2010guided fine needle aspiration and biopsy: A comprehensive review"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-1787","authenticated-orcid":false,"given":"Takuji","family":"Iwashita","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine Gifu University Hospital  Gifu 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