{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:04:20Z","timestamp":1777518260417,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>10\u2010mm self\u2010expandable metal stents (SEMSs) are commonly used for preoperative biliary drainage in pancreatic cancer. However, smaller diameter SEMSs have attracted attention with the attempt to reduce stent\u2010related adverse events (AEs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed consecutive borderline resectable pancreatic cancer patients who underwent neoadjuvant therapy and fully covered SEMS (FCSEMS) placement from April 2015 to May 2023. The primary outcome was stent\u2010related non\u2010event rate (NER), which was defined as the rate of completion of surgery without developing any preoperative events (recurrent biliary obstruction [RBO] or stent\u2010related AEs). Secondary outcomes included stent\u2010related AEs, causes of RBO, and cumulative incidence of RBO. Risk factors for pancreatitis, RBO, and stent migration were also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 76 patients were included (6\u2010mm group: 23; 10\u2010mm group: 53). Stent\u2010related NER (57% vs. 64%, <jats:italic>p<\/jats:italic> = 0.610), stent\u2010related AEs (4% vs. 15%, <jats:italic>p<\/jats:italic> = 0.263), overall RBO rates (39% vs. 23%, <jats:italic>p<\/jats:italic> = 0.168), cumulative incidence of RBO (hazard ratio, 2.24; 95% confidence interval, 0.95\u20135.25; <jats:italic>p<\/jats:italic> = 0.065) were not significantly different between the two groups. Tumor involvement of the pancreatic duct was identified as a risk\u2010reducing factor for pancreatitis, while an FCSEMS diameter of 6 mm was not identified as a risk factor for RBO and stent migration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Stent\u2010related NER was not significantly affected by FCSEMS diameter. Further studies are needed to confirm the usefulness of 6\u2010mm diameter FCSEMS for preoperative biliary drainage\u00a0in patients with borderline resectable pancreatic cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/deo2.360","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T02:28:20Z","timestamp":1712716100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes of 6\u2010mm diameter fully covered self\u2010expandable metal stents for preoperative biliary drainage in pancreatic cancer"],"prefix":"10.1002","volume":"4","author":[{"given":"Hiroki","family":"Nakagawa","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Medicine Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Department of Internal Medicine Division of Gastroenterology and Hepatology, Omori Medical Center Toho University  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