{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:28:31Z","timestamp":1768289311345,"version":"3.49.0"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal tumor. Some papers have reported that colonoscopy could be used to treat PEComa with a predominantly pedunculated polyp, whereas surgical intervention is often required for cases with submucosal\u2010type tumors. These findings suggest that the morphology of PEComa changes dramatically with disease progression. Because of the rapid progression of PEComa, endoscopic treatment remains challenging, and early\u2010stage PEComa morphology is not well understood. A 64\u2010year\u2010old man presented to our hospital for a follow\u2010up colonoscopy after undergoing multiple polypectomies. He had a medical history of colorectal adenoma and prostate cancer. A 4\u2010mm pale blue elevated but not pedunculated lesion was observed in the transverse colon, an area where he had not had polyps previously. Since no epithelial change was observed, the presence of a submucosal tumor, such as a gastrointestinal stromal tumor, was suspected. Cold snare polypectomy was performed, and the lesion was completely resected. Histological evaluation using hematoxylin and eosin staining identified that the submucosal tumor included thickened vascular walls and adipose tissue. Although fragmented due to significant degeneration, spindle\u2010shaped cells staining positive for smooth muscle actin\u00a0were observed within and surrounding the unstructured hyalinized tissue with calcifications. Based on these findings, the lesion was diagnosed as angiomyolipoma, a subtype of PEComa. Complete resection was confirmed by histopathology. To our knowledge, this PEComa is the smallest of any PEComa reported in the literature. Our finding provides valuable insights into the very early stage of colorectal PEComas.<\/jats:p>","DOI":"10.1002\/deo2.390","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T04:14:15Z","timestamp":1716264855000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A diminutive perivascular epithelioid cell tumor in the colon"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2630-8076","authenticated-orcid":false,"given":"Naoki","family":"Sugimura","sequence":"first","affiliation":[{"name":"Gastrointestinal Center &amp; Institute of Minimally\u2010Invasive Endoscopic Care (i\u2010MEC) Sano Hospital Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daizen","family":"Hirata","sequence":"additional","affiliation":[{"name":"Gastrointestinal Center &amp; Institute of Minimally\u2010Invasive Endoscopic Care (i\u2010MEC) Sano Hospital Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mineo","family":"Iwatate","sequence":"additional","affiliation":[{"name":"Gastrointestinal Center &amp; Institute of Minimally\u2010Invasive Endoscopic Care (i\u2010MEC) Sano Hospital Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5926-3417","authenticated-orcid":false,"given":"Santa","family":"Hattori","sequence":"additional","affiliation":[{"name":"Gastrointestinal Center &amp; Institute of Minimally\u2010Invasive Endoscopic Care (i\u2010MEC) Sano Hospital Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4673-7545","authenticated-orcid":false,"given":"Mikio","family":"Fujita","sequence":"additional","affiliation":[{"name":"Gastrointestinal Center &amp; Institute of Minimally\u2010Invasive Endoscopic Care (i\u2010MEC) Sano Hospital Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1401-5591","authenticated-orcid":false,"given":"Wataru","family":"Sano","sequence":"additional","affiliation":[{"name":"Gastrointestinal Center &amp; Institute of Minimally\u2010Invasive Endoscopic Care (i\u2010MEC) Sano Hospital Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Pathology Division Sano Hospital Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Sano","sequence":"additional","affiliation":[{"name":"Gastrointestinal Center &amp; Institute of Minimally\u2010Invasive Endoscopic Care (i\u2010MEC) Sano Hospital Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200206000-00018"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2018.03.012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31829caab3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2013.01.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-009-3973-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000393"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000173232.22117.37"}],"container-title":["DEN Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T12:46:35Z","timestamp":1746189995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/deo2.390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/deo2.390"],"URL":"https:\/\/doi.org\/10.1002\/deo2.390","archive":["Portico"],"relation":{},"ISSN":["2692-4609","2692-4609"],"issn-type":[{"value":"2692-4609","type":"print"},{"value":"2692-4609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,20]]},"assertion":[{"value":"2024-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e390"}}