{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T14:30:54Z","timestamp":1776522654495,"version":"3.51.2"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,22]],"date-time":"2024-09-22T00:00:00Z","timestamp":1726963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Pancreatic fibrosis is one of the main pathological features of chronic pancreatitis (CP), suggesting a strong relationship between CP and pancreatic ductal cancer. There was no available data about pancreatic fibrosis and pancreatic dysfunction in the early CP (ECP) using endosonography (EUS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Asymptomatic patients with pancreatic enzyme abnormalities (AP\u2010P; <jats:italic>n<\/jats:italic> = 56) and patients with ECP (<jats:italic>n<\/jats:italic> = 21) were determined by the absence of abnormal findings on upper gastrointestinal endoscopy, abdominal ultrasonography, and abdominal computed tomography. An Olympus EUS (GF\u2010UCT 260; Olympus) was used to perform EUS. Open software \u201cImage J\u201d, developed by NIH, was used to measure the surface area fraction of the designated elastic blue region. The maximum value among the pancreatic head, pancreatic body, and pancreatic tail was defined as the ELST\u2010blue score. The exocrine and endocrine pancreatic functions were evaluated using the <jats:italic>N<\/jats:italic>\u2010benzoyl\u2010l\u2010tyrosyl\u2010p\u2010aminobenzoic acid (BT\u2010PABA) test and homeostasis model assessment of \u03b2\u2010cell function (HOMA\u2010\u03b2) value, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EUS score, lobularity, and hyperechoic foci\/strands in patients with ECP were significantly (<jats:italic>p<\/jats:italic> &lt; 0.001) higher than those in patients with AP\u2010P. In addition, there were no significant differences in the BT\u2010PABA test (73.1 \u00b1 25.5, 68.5 \u00b1 15.6) and HOMA\u2010\u03b2 (93.1 \u00b1 67.4, 73.5 \u00b1 139.7) between patients with ECP and AP\u2010P. The ELST\u2010blue score measured by image J as the quantification tool in EUS strain elastography in patients with ECP was significantly higher (<jats:italic>p<\/jats:italic> = 0.002) than that in patients with AP\u2010P. Interestingly, the ELST\u2010blue score was significantly associated with HOMA\u2010\u03b2 in patients with ECP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The ELST\u2010blue score may be a useful tool for the evaluation of endocrine pancreatic dysfunction in the ECP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/deo2.407","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T05:21:42Z","timestamp":1727068902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Image J as the quantification tool in endosonography strain elastography may be reflected in the disturbance of endocrine pancreatic dysfunction"],"prefix":"10.1002","volume":"5","author":[{"given":"Ken","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School  Tokyo 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