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We herein report a 62\u2010year\u2010old male with severe COVID\u201019 who needed multidisciplinary treatment, including extracorporeal membrane oxygenation (ECMO). Despite the improvement in his respiratory status, GI bleeding developed. Capsule endoscopy and colonoscopy revealed extensive mucosal sloughing in the lower intestinal tract. Additionally, we performed a comprehensive analysis of the mRNA expression levels of various proinflammatory cytokines in the intestinal mucosal tissues. The results suggested a significant elevation of <jats:italic>IL\u20106<\/jats:italic>, which could be involved in the pathophysiology of the GI involvement in COVID\u201019. Further investigation with more clinical data, including endoscopic findings and molecular analyses, will contribute to a comprehensive understanding of COVID\u201019\u2010associated GI injury.<\/jats:p>","DOI":"10.1002\/deo2.42","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T18:36:30Z","timestamp":1631039790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Extensive mucosal sloughing of the small intestine and colon in a patient with severe COVID\u201019"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7733-4795","authenticated-orcid":false,"given":"Tsukasa","family":"Yamakawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Sapporo Medical University  Hokkaido 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