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Medical history taking, physical examinations, and laboratory testing are not adequately sensitive or specific, thus a colonoscopic investigation is frequently employed for etiological evaluation. However, for cases with non\u2010bloody chronic diarrhea, the diagnostic yield of a colonoscopy procedure is reported to be not high enough. Furthermore, endoscopically identifiable findings are not adequately specific for the diagnosis of diarrheal disease, except for inflammatory bowel disease, while microscopic colitis, amyloidosis, eosinophilic gastroenteritis, celiac disease, and bile acid diarrhea are difficult to definitively diagnose using endoscopic findings. Thus, a histopathological examination of biopsy samples obtained with endoscopy is critically important. Endoscopists should consider obtaining biopsy samples from even normal\u2010appearing gastrointestinal mucosa for chronic diarrhea diagnosis.<\/jats:p>","DOI":"10.1002\/deo2.53","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T21:34:35Z","timestamp":1632864875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Endoscopic diagnosis of chronic diarrhea"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5708-985X","authenticated-orcid":false,"given":"Yoshikazu","family":"Kinoshita","sequence":"first","affiliation":[{"name":"Department of Medicine Hyogo Brain and Heart Center  Hyogo Japan"},{"name":"Department of Gastroenterology Steel Memorial Hirohata Hospital  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Ariyoshi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology 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