{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:06:10Z","timestamp":1785855970331,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Based on the recent therapeutic trends for gastric cancer (GC), the clinical impact of the diagnosis of Epstein\u2013Barr virus (EBV)\u2010associated GC (EBVaGC) appears to be important. We retrospectively analyzed endoscopic and pathologic motifs of GC lesions to narrow the number of candidates for EBV testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed EBV tests for 32 upper gastrointestinal lesions of 32 patients in the clinical setting. These tests were ordered by endoscopists or by pathologists without an endoscopist's order. EBV\u2010encoded small RNA1 (EBER1) in situ hybridization was used for the EBV tests. The endoscopic motif for the EBV test was the location in the upper part of the stomach or remnant stomach, mainly the depressed type with a submucosal tumor\u2010like protrusion of the lesion. The pathologic motif was carcinoma with lymphoid stroma (CLS) or CLS\u2010like histology of the lesion. We retrospectively analyzed the results of EBV tests for the endoscopic and pathologic motifs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final pathological diagnoses of the 32 subjects were 26 GCs including CLS, gastric endocrine cell carcinoma, gastric hepatoid carcinoma, gastric T\u2010cell lymphoma, gastritis of the remnant stomach, esophageal adenocarcinoma, and esophageal squamous cell carcinoma. When nontypical lesions were excluded, the EBER1\u2010positive rate was 42.3% (11\/26) in GCs. Of the 14 GC lesions ordered examined by endoscopists, three (21.4%) were EBVaGC. Eight of the 12 (66.7%) GCs ordered examined by pathologists were EBVaGC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The pathologic motif is expected to be useful and the endoscopic motif may be helpful for EBVaGC diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/deo2.7","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T04:38:10Z","timestamp":1619066290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Endoscopic and pathologic motifs for the clinical diagnosis of Epstein\u2013Barr virus\u2010associated gastric cancer"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4374-0792","authenticated-orcid":false,"given":"Hideo","family":"Yanai","sequence":"first","affiliation":[{"name":"Department of Clinical Research National Hospital Organization Kanmon Medical Center  Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Chihara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology National Hospital Organization Kanmon Medical Center  Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Harano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology National Hospital Organization Kanmon Medical Center  Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiki","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology &amp; Hepatology National Hospital Organization Kanmon Medical Center  Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital Organization Kanmon Medical Center  Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Laboratory Science Graduate School of Medicine, Yamaguchi University  Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13480"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.05.001"},{"key":"e_1_2_8_4_1","first-page":"574","article-title":"Epatein\u2010Barr virus related gastric cancer in Japan: a molecular patho\u2010epidemiological study","volume":"43","author":"Tokunaga M","year":"1993","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_8_5_1","first-page":"769","article-title":"Epstein\u2013Barr virus\u2010associated gastric adenocarcinoma","volume":"140","author":"Shibata D","year":"1992","journal-title":"Am J 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Epstein\u2013Barr virus\u2010associated gastric carcinoma","volume":"52","author":"Nakamura Y","year":"2005","journal-title":"Hepatogastroenterology"}],"container-title":["DEN 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