{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:37:43Z","timestamp":1790865463444,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In gastroenterology, sedation demand is increasing, although elderly patients are more prone to experiencing adverse events. Remimazolam, a novel ultra\u2010short\u2010acting benzodiazepine, may reduce recovery time after endoscopic procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was a secondary analysis of the investigator\u2010initiated trial, which investigated the efficacy and safety of remimazolam in gastrointestinal endoscopy (REM\u2010IICT JP01). Remimazolam sedation was administered during upper gastrointestinal endoscopy. Patients were divided into two groups: 45 non\u2010elderly and 11 elderly patients (aged \u226565 years). The primary outcome was sedation success. Secondary outcomes included the dose required for sedation, time to awakening, time to regain the ability to walk, and occurrence of adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Endoscopic sedation was successful in 95.6% of the non\u2010elderly group and 100% of the elderly group. The total dose of remimazolam was significantly higher in the non\u2010elderly group (4.0 [3.0\u20138.0] mg) than in the elderly group (3.0 [2.0\u20133.0] mg;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). The time to awakening was 0.0 (0.0\u201310.0) min in the non\u2010elderly group compared to 0.0 (0.0\u201330.0) min (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.98) in the elderly group. The time to regain the ability to walk was significantly longer in the elderly group (5.0 [0.0\u201360.0] min) than in the non\u2010elderly group (5.0 [0.0\u201330.0] min;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03). During the procedure, adverse events included hypotension in two cases (4.4%) in the non\u2010elderly group and hypoxemia in one case (9.0%) in the elderly group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Upper gastrointestinal endoscopy with remimazolam was effective and safe, regardless of age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70057","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T05:18:29Z","timestamp":1737004709000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Usefulness and safety of remimazolam in upper gastrointestinal endoscopy: A comparative study between elderly and non\u2010elderly patients"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5977-3660","authenticated-orcid":false,"given":"Ryoji","family":"Ichijima","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"},{"name":"Department of Gastroenterology Saiseikai Kawaguchi General Hospital Saitama Japan"},{"name":"Department of Gastroenterology Kiriyama Clinic Gunma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9239-7495","authenticated-orcid":false,"given":"Hisatomo","family":"Ikehara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"},{"name":"Department of Gastroenterology Kitasato University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9782-9998","authenticated-orcid":false,"given":"Daisuke","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Hospital Organization Ureshino Medical Center Saga Japan"},{"name":"Division of Gastroenterology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nagata Surgery and Gastroenterological Clinic Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nagata Surgery and Gastroenterological Clinic Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-2153","authenticated-orcid":false,"given":"Mitsuru","family":"Esaki","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-9738","authenticated-orcid":false,"given":"Yosuke","family":"Minoda","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ono","sequence":"additional","affiliation":[{"name":"Division of Endoscopy Shizuoka Cancer Center Shizuoka 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