{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T18:07:31Z","timestamp":1768414051963,"version":"3.49.0"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the initial diagnosis\u00a0of superficial esophageal squamous cell carcinoma, a 70\u2010year\u2010old man was treated with endoscopic submucosal dissection (ESD). Two years after the first ESD, follow\u2010up endoscopy revealed that the extent of hyperkeratosis gradually expanded over the following 4 years; however, biopsies conducted only detected <jats:italic>Candida<\/jats:italic> mycelia and no cancer at that time and every 6 months for 4 years. Despite initiating fluconazole treatment for persistent <jats:italic>Candida<\/jats:italic> esophagitis 6 years after the first ESD, the lesions did not resolve, and the second ESD was performed 6 years after the first ESD, which revealed squamous cell carcinoma. This case highlights that esophageal cancer should be considered when localized, hyperkeratotic <jats:italic>Candida<\/jats:italic> esophagitis is unresponsive to antifungal treatments, especially with a history of esophageal cancer or high\u2010risk factors such as drinking alcohol and smoking.<\/jats:p>","DOI":"10.1002\/deo2.70080","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T14:45:16Z","timestamp":1739544316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Surrounding superficial esophageal cancer masked by <i>Candida<\/i> esophagitis that was difficult to distinguish from <i>Candida<\/i> esophagitis alone: A case report"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2854-6926","authenticated-orcid":false,"given":"Shunsuke","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.11641\/pde.95.1_35"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12195"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80347-2"},{"key":"e_1_2_8_5_1","first-page":"1","article-title":"Diagnosis and treatment of esophageal candidiasis: Current updates","volume":"9","author":"Abdimajid M","year":"2019","journal-title":"Can J Gastroenterol Hepatol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3684"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.03.006"}],"container-title":["DEN Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.70080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T12:45:08Z","timestamp":1746189908000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/deo2.70080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,14]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/deo2.70080"],"URL":"https:\/\/doi.org\/10.1002\/deo2.70080","archive":["Portico"],"relation":{},"ISSN":["2692-4609","2692-4609"],"issn-type":[{"value":"2692-4609","type":"print"},{"value":"2692-4609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,14]]},"assertion":[{"value":"2024-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70080"}}