{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:27:40Z","timestamp":1791779260934,"version":"4.3.4"},"reference-count":71,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> eradication reduces but cannot eliminate the risk of gastric cancer (GC). The prevalence of post\u2010eradication GC has been rising. Characterization of the endoscopic findings of post\u2010eradication GC may facilitate its early detection. We performed a meta\u2010analysis and systematic review to clarify endoscopic risk factors to accelerate the early diagnosis of post\u2010eradication GC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medline and PubMed were searched for randomized controlled trials, cohort studies, and case\u2010control studies published in the English\u2010language medical literature between January 1997 and July 2023. The included articles assessed the correlation between post\u2010eradication GC and pre\u2010 and post\u2010eradication endoscopic findings, and associated post\u2010eradication GC with gastric atrophy, intestinal metaplasia (IM), map\u2010like redness, and xanthoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 963 articles were retrieved. In these articles, 66 papers were finally included, comprising randomized controlled trials, cohort studies, and case\u2010control studies. The included articles addressed gastric atrophy (16 studies), IM (eight studies), map\u2010like redness (six studies), and xanthoma (two studies). Risk ratio (RR) of incident post\u2010eradication GC was 3.40 (95%confidence interval [95%CI]: 1.98\u20135.84; <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001) in cases of severe atrophy, 5.38 (95%CI: 3.62\u20138.00) in cases of severe IM, 2.34 (95%CI: 1.16\u20134.68) in cases with post\u2010eradication map\u2010like redness, and 2.75 (95% CI: 1.78\u20134.26) in cases with xanthoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Endoscopic atrophy, IM, and xanthoma observed at pre\u2010 and post\u2010eradication time points and post\u2010eradication map\u2010like redness were suggested as endoscopic risk factors for post\u2010eradication GC. Further studies are needed to clarify the risk of post\u2010eradication GC based on these risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/deo2.70086","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T22:53:12Z","timestamp":1741647192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Endoscopic risk factors to inform early detection of gastric cancer after <i>Helicobacter pylori<\/i> eradication: Meta\u2010analysis and systematic review"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-9470","authenticated-orcid":false,"given":"Masaaki","family":"Kodama","sequence":"first","affiliation":[{"name":"Department of Advanced Medical Sciences Faculty of Medicine Oita University Oita Japan"},{"name":"Department of Gastroenterology Faculty of Medicine Oita University Oita 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