{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:09:19Z","timestamp":1790172559890,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The diagnosis of gallbladder (GB) lesions relies on imaging findings. Transpapillary cholangioscopy can potentially be used to diagnose GB lesions; however, the images obtained remain unclear. This study aimed to characterize the endoscopic findings of GB lesions. We examined the endoscopic features of GB lesions in 50 consecutive patients who underwent cholecystectomy. GB specimens were obtained immediately following cholecystectomy, opened on the side opposite the liver bed, and flushed with saline solution. Each lesion was assessed using a high\u2010resolution endoscope equipped with white light and narrow\u2010band imaging magnification. For elevated lesions, both the surface structure (classified as regular, irregular, or absent) and vascular structure (dilation, meandering, caliber change, non\u2010uniformity, and loose vessel areas) were assessed. Twelve of the 50 patients had elevated lesions, including cholesterol polyp (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a04), hyperplastic polyp (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01), xanthogranulomatous cholecystitis (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a01), and GB carcinoma (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06). Advanced GB carcinoma, as opposed to T1 GB carcinoma, demonstrated a papillary surface with destructive areas and neovascularization on narrow\u2010band imaging magnification. Endoscopic images of each GB lesion were characterized, and the differences between GB carcinomas and benign lesions were identified. This preliminary classification may contribute to innovative imaging diagnosis and targeted biopsy for diagnosing GB lesions under direct vision.\n                  <\/jats:p>","DOI":"10.1002\/deo2.70136","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T08:31:34Z","timestamp":1746261094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic findings of gallbladder lesions evaluated with image\u2010enhanced endoscopy: A preliminary study using resected gallbladders"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1793-1587","authenticated-orcid":false,"given":"Kiyoyuki","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Division of Innovative Medicine for Hepatobiliary and Pancreatology Faculty of Medicine Kagawa University  Kagawa Japan"},{"name":"Department of Internal Medicine Kagawa Rosai Hospital  Kagawa Japan"},{"name":"Department of Gastroenterology and Hepatology HITO Medical Center  Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Ayaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology HITO Medical Center  Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology HITO Medical Center  Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaho","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kagawa Rosai Hospital  Kagawa Japan"},{"name":"Department of Gastroenterology and Neurology Faculty of Medicine Kagawa University  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Tokumo","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery Kagawa Rosai Hospital  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Kokudo","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery Kagawa Rosai Hospital  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Morito","sequence":"additional","affiliation":[{"name":"Department of Pathology Kagawa Rosai Hospital  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Faculty of Medicine Kagawa University  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Faculty of Medicine Kagawa University  Kagawa 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University  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology Faculty of Medicine Kagawa University  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1035-6660","authenticated-orcid":false,"given":"Naoki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology Faculty of Medicine Kagawa University  Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8508-827X","authenticated-orcid":false,"given":"Hiroki","family":"Yamana","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology Faculty of Medicine Kagawa University  Kagawa 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