{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:11:10Z","timestamp":1790172670979,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Precut sphincterotomy is often performed when bile duct cannulation is difficult; however, the former has a higher risk of complications than conventional methods. Early precut reduces the risk of post\u2010endoscopic retrograde cholangiopancreatography pancreatitis (PEP). This study aimed to determine the appropriate timing for precut sphincterotomy to minimize the incidence of PEP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study analyzed 320 patients who underwent precut sphincterotomy during their first endoscopic retrograde cholangiopancreatography at a single center. The optimal precut timing was identified using receiver operating characteristic analysis. Patients were divided into an optimized precut group (\u226412\u00a0min,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0198) and a delayed group (&gt;12\u00a0min,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0122). The incidence and risk factors of PEP were evaluated using multivariate analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Receiver operating characteristic analysis identified 12.5\u00a0min as the optimal cutoff for transitioning to precut sphincterotomy (area under the curve, 0.613; sensitivity, 61.5%; specificity, 63.9%). The incidence of PEP was significantly lower in the optimized precut group than in the delayed precut group (5.1%\u00a0vs. 13.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02). Multivariate analysis identified delayed precut timing (odds ratio [OR], 3.134;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04) and the absence of endoscopic pancreatic stenting (OR, 0.284;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01) as independent risk factors for PEP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Precut sphincterotomy within 12.5\u00a0min of a cannulation attempt reduces the risk of PEP while maintaining procedural safety. Additionally, endoscopic pancreatic stenting\u00a0can reduce PEP, even in precut scenarios.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70138","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T11:53:55Z","timestamp":1746532435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimal timing of precut sphincterotomy to prevent post\u2010endoscopic retrograde cholangiopancreatography pancreatitis in difficult biliary cannulation: A retrospective study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9766-9007","authenticated-orcid":false,"given":"Tomohiro","family":"Tanikawa","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine 2 Kawasaki Medical School  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine 2 Kawasaki Medical School  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuko","family":"Kawada","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine 2 Kawasaki Medical School  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine 2 Kawasaki Medical School  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Fushimi","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine 2 Kawasaki Medical School  Okayama 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