{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:44:52Z","timestamp":1793727892100,"version":"4.6.1"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Gastric cancer (GC) remains a major global health concern, particularly in East Asia, Central Asia, and Eastern Europe, where its incidence and mortality rates are high.\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection is the primary cause of GC and leads to carcinogenic progression from nonatrophic gastritis to cancer. Although screening programs have been implemented in high\u2010risk countries, such as Japan and South Korea, comprehensive strategies remain limited globally. This study reviewed the status of GC screening worldwide and prevention strategies in regions with different risks. Various GC screening methods have been developed, including\n                    <jats:italic>H. pylori<\/jats:italic>\n                    serology, serum pepsinogen testing, upper gastrointestinal contrast radiography, and endoscopy. Endoscopic screening has shown superior sensitivity and specificity, reducing GC mortality by up to 47% in South Korea and demonstrating higher detection rates than upper gastrointestinal\u00a0contrast radiography and pepsinogen testing. However, cost\u2010effectiveness remains a challenge, particularly in Western countries where the overall GC prevalence is lower. Risk stratification using a combination of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    serology and pepsinogen\u00a0testing has been adopted in Japan to optimize screening efficiency. Additionally,\n                    <jats:italic>H. pylori<\/jats:italic>\n                    eradication has been recognized as a cost\u2010effective strategy to reduce the incidence of GC with economic benefits demonstrated in Japan and other high\u2010risk regions. In the United States, targeted screening of high\u2010risk immigrant populations has been suggested to enhance cost\u2010effectiveness. GC screening strategies should consider developing epidemiological trends, cost\u2010effectiveness, and risk\u2010based approaches. Future efforts should focus on expanding targeted screening initiatives to high\u2010risk groups to improve early detection and survival rates.\n                  <\/jats:p>","DOI":"10.1002\/deo2.70148","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T23:34:58Z","timestamp":1748302498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Current Status of Gastric Cancer Screening and Future Perspectives"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3789-4787","authenticated-orcid":false,"given":"Chika","family":"Kusano","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Gastroenterology and Hepatology Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology International University of Health and Welfare Ichikawa Hospital  Ichikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9210-7371","authenticated-orcid":false,"given":"Chikamasa","family":"Ichita","sequence":"additional","affiliation":[{"name":"Gastroenterology Medicine Center Shonan Kamakura General Hospital  Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Gotoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cancer Institute Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28999"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70137-7"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30488-7"},{"key":"e_1_2_5_6_1","first-page":"3554","article-title":"A Human Model of Gastric Carcinogenesis","volume":"48","author":"Correa P.","year":"1988","journal-title":"Cancer Research"},{"key":"e_1_2_5_7_1","first-page":"26","article-title":"Epidemiology of Gastric Cancer: Global Trends, Risk Factors and Prevention","volume":"14","author":"Rawla P.","year":"2019","journal-title":"Przegl\u0105d Gastroenterologiczny"},{"key":"e_1_2_5_8_1","unstructured":"Heightened Risk for Gastric Cancer Among Immigrant Populations in New York State From High\u2010Incidence Countries\u2014Clinical Key [Internet]. 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