{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:10:31Z","timestamp":1790172631343,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Wirsungocele, a cystic dilation at the end of the main pancreatic duct, is associated with recurrent acute pancreatitis. A 52\u2010year\u2010old man presented to our hospital with recurrent epigastric pain over an 8\u2010month period with a history of multiple medical visits for the same complaint. Endoscopic ultrasound (EUS) and magnetic resonance cholangiopancreatography (MRCP) revealed focal cystic dilatation at the end of the main pancreatic duct; thus, he was diagnosed with Wirsungocele. He underwent endoscopic pancreatic sphincterotomy and 5Fr 4\u00a0cm pancreatic duct stent placement; the pancreatic duct stent was removed 1 month later. Magnetic resonance imaging performed 3 months after discharge revealed no cystic dilation, and he has had no recurrence of pancreatitis for at least 6 months. Dysfunction of the sphincter of Oddi, weakening of the pancreatic duct wall, inflammation and recurrent stress, elevated intraductal pressure, and genetic and structural factors are suspected mechanisms behind the pathophysiology of Wirsungocele. Although the etiology of Wirsungocele is not known, its timely identification and treatment are critical to preventing recurrent episodes of pancreatitis. This case demonstrates the diagnostic value of combining MRCP and EUS as well as the therapeutic benefits of endoscopic intervention, including sphincterotomy and stent placement, in managing Wirsungocele\u2010associated recurrent pancreatitis. Given the paucity of reports on recurrent pancreatitis due to the Wirsungocele, we herein report this case and review the literature.<\/jats:p>","DOI":"10.1002\/deo2.70156","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T22:59:43Z","timestamp":1749164383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wirsungocele as a Rare Cause of Recurrent Pancreatitis: Etiology and Therapeutic Insights"],"prefix":"10.1002","volume":"6","author":[{"given":"Sorano","family":"Ichiya","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  3\u201018\u201022 Honkomagome Bunkyo\u2010Ku Tokyo 113\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1434-3410","authenticated-orcid":false,"given":"Jun","family":"Nakahodo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  3\u201018\u201022 Honkomagome Bunkyo\u2010Ku Tokyo 113\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Imaeda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  3\u201018\u201022 Honkomagome Bunkyo\u2010Ku Tokyo 113\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4284-9574","authenticated-orcid":false,"given":"Ryogo","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  3\u201018\u201022 Honkomagome Bunkyo\u2010Ku Tokyo 113\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Kakizaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  3\u201018\u201022 Honkomagome Bunkyo\u2010Ku Tokyo 113\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Ujita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  3\u201018\u201022 Honkomagome Bunkyo\u2010Ku Tokyo 113\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Tabata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  3\u201018\u201022 Honkomagome Bunkyo\u2010Ku Tokyo 113\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuro","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  3\u201018\u201022 Honkomagome Bunkyo\u2010Ku Tokyo 113\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  3\u201018\u201022 Honkomagome Bunkyo\u2010Ku Tokyo 113\u20108677 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.20.24857"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)00292-5"},{"key":"e_1_2_9_4_1","first-page":"531","article-title":"Recurrent Acute Pancreatitis and Wirsungocele","volume":"9","author":"Gupta R.","year":"2008","journal-title":"Journal of Pancreas"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-020-02675-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573405617666210804153921"},{"key":"e_1_2_9_7_1","first-page":"99","article-title":"Recurrent Acute Pancreatitis in a Patient With Wirsungocele and Neuroendocrine Tumor of Ampulla of Vater","volume":"14","author":"Dhir V.","year":"2013","journal-title":"Journal of Pancreas"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/eus.eus_77_20"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1046-1940"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-019-02004-4"}],"container-title":["DEN Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.70156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/deo2.70156","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.70156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:58:22Z","timestamp":1790171902000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/deo2.70156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/deo2.70156"],"URL":"https:\/\/doi.org\/10.1002\/deo2.70156","archive":["Portico"],"relation":{},"ISSN":["2692-4609","2692-4609"],"issn-type":[{"value":"2692-4609","type":"print"},{"value":"2692-4609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]},"assertion":[{"value":"2025-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70156"}}