{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:28:54Z","timestamp":1793809734472,"version":"4.6.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the usefulness of the ELST\u2010blue score to explore its potential application in identifying high\u2010risk groups for early chronic pancreatitis (ECP) through reflecting on pancreatic elasticity and the reduction of pancreatic function, and we tried to demonstrate whether the ELST\u2010blue score was significantly associated with apolipoprotein A2 (apoA2) isoforms in patients with ECP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010four patients with pancreatic enzyme abnormalities underwent endosonography. We divided two groups, one group was patients with ECP (\n                      <jats:italic>n<\/jats:italic>\n                      = 16) and the other group was patients with non\u2010ECP (\n                      <jats:italic>n<\/jats:italic>\n                      = 28). ELST\u2010blue was defined using the open\u2010source software \u2018Image J\u2019. The concentration of apoA2 isoforms was measured using an enzyme\u2010linked immunosorbent assay kit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Epigastric pain tended to be more severe in patients with ECP than in those without ECP. There was a significant difference in the diameter of the main pancreatic duct of more than 2\u00a0mm as well as in stranding or hyperechoic foci and lobularity between patients with ECP and non\u2010ECP. The ELST\u2010blue score was significantly higher in patients with ECP than in non\u2010ECP (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003). Although an intense negative correlation was determined between ELST\u2010blue score and the apoA2\u2010i Index in patients with ECP (r = \u20100.704,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002), there was no significant relationship between ELST\u2010blue score and apoA2\u2010I Index in patients with non\u2010ECP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with ECP accompanied by a high score of ELST\u2010blue have to be followed up carefully.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70191","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:05:01Z","timestamp":1756461901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High Score of ELST\u2010Blue in Endoscopic Ultrasonography Strain Elastography May Provide a High Risk Group of Early Chronic Pancreatitis with the Reduction of Apolipoprotein A2\u2010i Index"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5723-1491","authenticated-orcid":false,"given":"Ken","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0502-8646","authenticated-orcid":false,"given":"Seiji","family":"Futagami","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Agawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School  Tokyo 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School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Kirita","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyu","family":"Sai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Itokawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobue","family":"Ueki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Internal 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