{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:03:27Z","timestamp":1791407007422,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Approximately 10%\u201330% patients with familial adenomatous polyposis (FAP) develop gastric neoplasms (GNs). Although recent reports have suggested the effectiveness of gel\u2010immersion endoscopic mucosal resection (GI\u2010EMR) for FAP\u2010associated GNs, given its simplicity and safety, treatment outcomes for such lesions have not been evaluated. We aimed to investigate the efficacy and safety of GI\u2010EMR compared with endoscopic submucosal dissection (ESD) for GNs in patients with FAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicenter, retrospective study, treatment outcomes of ESD and GI\u2010EMR for GNs measuring \u226420\u00a0mm with protruding or flat elevated morphology between April 2011 and November 2024 were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study included 15 ESD and 12 GI\u2010EMR cases. En bloc and R0 resection rates did not significantly differ between the ESD and GI\u2010EMR groups (100%\u00a0vs. 100% and 100%\u00a0vs. 83.3%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.19, respectively). The procedure time was significantly shorter for GI\u2010EMR than for ESD (2\u00a0vs. 47\u00a0min,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001, respectively). Intraprocedural perforation occurred in 6.7% of ESD cases, but was not observed in the GI\u2010EMR group. Neither delayed bleeding nor perforation occurred in any group. During the median follow\u2010up period of 22.3 months, no local recurrence was observed in either group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GI\u2010EMR may be considered one of the therapeutic options for GNs in patients with FAP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70209","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:05:01Z","timestamp":1758708301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and Safety of Gel Immersion Endoscopic Mucosal Resection for Gastric Neoplasms in Patients With Familial Adenomatous Polyposis: A Multicenter Retrospective Study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0818-4153","authenticated-orcid":false,"given":"Hidenori","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Digestive Endoscopy Shiga University of Medical Science  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Shigeta","sequence":"additional","affiliation":[{"name":"Division of Endoscopy Shizuoka Cancer Center  Nagaizumi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Yabuuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kobe City Medical Center General Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Endoscopy Shizuoka Cancer Center  Nagaizumi 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