{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:09:22Z","timestamp":1790172562590,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>There is limited evidence on the diagnostic yield of endoscopic ultrasound (EUS)\u2010guided tissue acquisition (TA) using fine\u2010needle biopsy (FNB) in autoimmune pancreatitis (AIP), particularly considering the newer end\u2010cutting needles. The aim of this meta\u2010analysis was to provide a pooled estimate of the diagnostic performance of EUS\u2010TA using FNB in AIP patients according to the needle type used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A computerized bibliographic search was performed through April 2024. Pooled effects were calculated using a random\u2010effects model. The primary endpoint was diagnostic accuracy. Secondary outcomes were sample adequacy, rates of adequate material for levels 1 and 2 of histological diagnosis, definitive diagnosis reached with histology in addition to imaging\/laboratory tests, and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve studies (three prospective series and one randomized trial) with 496 patients were included. Overall diagnostic accuracy rate was 75% (66%\u201383%), with a superiority of end\u2010cutting needles over reverse bevel needles (80%, 70%\u201390% versus 49%, 21%\u201367%;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Franseen (81%, 68%\u201393%) and Fork\u2010tip needles (86%, 74%\u201398%) showed the highest accuracy. Sample adequacy rate was 92% (87%\u201398%), and EUS\u2010TA using FNB provided level 1 of histological diagnosis in 47% of cases (38%\u201357%) and level 2 in 23% (16%\u201330%). EUS\u2010TA using FNB provided a definitive diagnosis in 77% (63%\u201391%) of cases. Pooled rate of adverse event was 2% (1%\u20133%), mainly mild pancreatitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>End\u2010cutting needles showed high diagnostic yield in patients with AIP, with a low rate of adverse events, and should be preferred over reverse bevel needles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70239","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:14:53Z","timestamp":1762283693000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Endoscopic Ultrasound\u2010guided Fine\u2010Needle Biopsy With End\u2010Cutting Needles in Autoimmune Pancreatitis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"6","author":[{"given":"Antonio","family":"Facciorusso","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine Universit\u00e0 del Salento  Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina Conti","family":"Bellocchi","sequence":"additional","affiliation":[{"name":"Department of Medicine Gastroenterology and Digestive Endoscopy University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"De Pretis","sequence":"additional","affiliation":[{"name":"Department of Medicine Gastroenterology and Digestive Endoscopy University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Frulloni","sequence":"additional","affiliation":[{"name":"Department of Medicine Gastroenterology and Digestive Endoscopy University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4560-8741","authenticated-orcid":false,"given":"Stefano Francesco","family":"Crin\u00f2","sequence":"additional","affiliation":[{"name":"Department of Medicine Gastroenterology and Digestive Endoscopy University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3182142fd2"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640620934911"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11091653"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.10.020"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2022.01.019"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2156-0063"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1293-7279"},{"key":"e_1_2_12_9_1","article-title":"The Cochrane Collaboration's Tool for Assessing Risk of Bias in Randomised Trials","volume":"18","author":"Higgins J. 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Available from http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.htmAccessed: May 2024."},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.02.022"},{"key":"e_1_2_12_12_1","unstructured":"The jamovi Project.jamovi (Version 2.5) [Computer Software](2024) https:\/\/www.jamovi.orgAccessed: May 2024."},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-009-0062-6"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12102464"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2015.03.011"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.10.012"},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"AB357","DOI":"10.1016\/j.gie.2017.03.826","article-title":"Comparison of 19g versus 22G Reverse Side\u2010Bevel Needles for Endoscopic Ultrasound\u2010Guided Pancreatic Core Biopsy of Autoimmune Pancreatitis","volume":"85","author":"Lee S. 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