{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:10:34Z","timestamp":1790172634698,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peroral endoscopic myotomy (POEM) is an effective treatment for achalasia; however, accurately identifying the distal extent of myotomy remains a technical challenge. Indocyanine green with infrared imaging (ICG\u2010IRI) may facilitate the intraoperative visualization of the esophagogastric junction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated 39 patients who underwent POEM using ICG\u2010IRI. The primary outcome was the success rate of ICG\u2010IRI, defined as a clear endoscopic visualization of fluorescence at the distal myotomy endpoint. The secondary outcomes included technical success, changes in integrated relaxation pressure, and Eckardt scores before and after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The technical success rate was 100%, and ICG\u2010IRI was successful in 94.9% of the cases (37\/39). The median integrated relaxation pressure decreased from 26.9\u00a0to 10.8\u00a0mmHg, and the median Eckardt score improved from 5.0 to 1.0 (both\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). No adverse events were attributed to the ICG\u2010IRI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The ICG\u2010IRI method is a reliable visual aid for identifying distal myotomy endpoints during POEM. This technique may enhance the procedural accuracy and improve clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70250","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T17:40:58Z","timestamp":1765388458000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced Visualization of the Distal Myotomy Endpoint during Peroral Endoscopic Myotomy Using Indocyanine Green With Infrared Imaging"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-8584","authenticated-orcid":false,"given":"Yuichiro","family":"Ikebuchi","sequence":"first","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"},{"name":"Division of Internal Medicine Motomachi Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuki","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moe","family":"Eizawa","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Mikamo","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Ogihara","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Kamitani","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirai","family":"Edano","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehito","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kurumi","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Yashima","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-7865","authenticated-orcid":false,"given":"Hajime","family":"Isomoto","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Internal Medicine Division of Gastroenterology and Nephrology Tottori University Hospital Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60651-0"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13491"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1244080"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(25)00012-3"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11049"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1099533"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1753-9801"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-015-4396-2"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13869"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-5157(18)30071-0"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-017-0589-1"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14058"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-019-01608-3"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2.172"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1753-9801"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.15008"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.15008"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002311"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001800"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1483-9406"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1894-0147"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12328"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14814"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vgie.2020.05.034"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.01.043"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v15.i5.757"}],"container-title":["DEN Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.70250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/deo2.70250","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.70250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:56:57Z","timestamp":1790171817000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/deo2.70250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/deo2.70250"],"URL":"https:\/\/doi.org\/10.1002\/deo2.70250","archive":["Portico"],"relation":{},"ISSN":["2692-4609","2692-4609"],"issn-type":[{"value":"2692-4609","type":"print"},{"value":"2692-4609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]},"assertion":[{"value":"2025-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70250"}}