{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:29:06Z","timestamp":1793809746077,"version":"4.6.1"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Gastroparesis is a chronic gastric motility disorder marked by delayed gastric emptying in the absence of mechanical obstruction. For patients with symptoms refractory to medical and dietary therapy, Gastric Peroral Endoscopic Myotomy (G\u2010POEM) has emerged as a minimally invasive, pylorus\u2010targeted intervention that directly addresses pyloric dysfunction.<\/jats:p>\n                  <jats:p>Technical success rates consistently exceed 95%, reflecting procedural standardization and a favorable learning curve. Short\u2010term symptom improvement is reported in up to 80% of patients and is often accompanied by enhanced gastric emptying and quality of life (QOL). Long\u2010term outcomes show sustained clinical success of 50%\u201377.5% at 3\u20134 years, influenced by disease etiology and neuromuscular progression. Endoluminal functional lumen imaging probe, a functional imaging tool that measures pyloric distensibility, has shown promise in identifying optimal candidates and assessing procedural efficacy, though standardized predictive thresholds are still lacking.<\/jats:p>\n                  <jats:p>Overall, G\u2010POEM has become a leading pylorus\u2010directed therapy for refractory gastroparesis. Comparative data suggest that G\u2010POEM offers superior clinical efficacy and durability relative to botulinum toxin injection and gastric electrical stimulation, with fewer complications than surgical pyloroplasty.<\/jats:p>\n                  <jats:p>This review integrates the current clinical evidence supporting G\u2010POEM, with a focus on patient selection, procedural outcomes, QOL, and durability of response. It also examines comparative data with alternative therapies and addresses ongoing areas of controversy, including procedural technique, repeat intervention, and the predictive value of prior pyloric\u2010directed therapies. G\u2010POEM represents a safe and effective treatment modality for appropriately selected patients and continues to shape the landscape of gastroparesis management.<\/jats:p>","DOI":"10.1002\/deo2.70260","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T13:00:54Z","timestamp":1765285254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Redefining the Treatment Landscape in Gastroparesis: A Clinical Review of Gastric Peroral Endoscopic Myotomy Outcomes and Therapeutic Integration"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2159-3545","authenticated-orcid":false,"given":"Kobina","family":"Essilfie\u2010Quaye","sequence":"first","affiliation":[{"name":"University of Central Florida College of Medicine  Orlando Florida USA"},{"name":"Department of Internal Medicine HCA Florida North Florida Hospital  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carson","family":"Creamer","sequence":"additional","affiliation":[{"name":"University of Central Florida College of Medicine  Orlando Florida USA"},{"name":"Department of Internal Medicine HCA Florida North Florida Hospital  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Abuassi","sequence":"additional","affiliation":[{"name":"University of Central Florida College of Medicine  Orlando Florida USA"},{"name":"Department of Internal Medicine HCA Florida North Florida Hospital  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsimran","family":"Kalsi","sequence":"additional","affiliation":[{"name":"University of Central Florida College of Medicine  Orlando Florida USA"},{"name":"Department of Internal Medicine HCA Florida North Florida Hospital  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeka","family":"Akhavan","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Brar","sequence":"additional","affiliation":[{"name":"University of Central Florida College of Medicine  Orlando Florida USA"},{"name":"Center For Advanced Therapeutic Endoscopy (CATE) HCA Florida North Florida Hospital  Gainesville Florida USA"},{"name":"Digestive Disease Associates  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaseen","family":"Perbtani","sequence":"additional","affiliation":[{"name":"University of Central Florida College of Medicine  Orlando Florida USA"},{"name":"Center For Advanced Therapeutic Endoscopy (CATE) HCA Florida North Florida Hospital  Gainesville Florida USA"},{"name":"Digestive Disease Associates  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