{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:09:29Z","timestamp":1790172569976,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Remimazolam is a novel ultra\u2013short\u2010acting benzodiazepine that may offer advantages over conventional sedatives in endoscopic procedures. Evidence for its use in pancreatobiliary endoscopic ultrasonography (EUS) is limited. We compared the efficacy and safety of remimazolam and midazolam in outpatient pancreatobiliary EUS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included outpatients undergoing diagnostic pancreatobiliary EUS between July 2024 and July 2025. Patients received either remimazolam (initial 0.2\u00a0mg\/kg, top\u2010up 0.1\u00a0mg\/kg [high\u2010risk patients: 0.16\u00a0mg\/kg, 0.08\u00a0mg\/kg]) or midazolam. The target sedation depth was Modified Observer's Assessment of Alertness\/Sedation \u22643, procedures were performed without supplemental oxygen, and pentazocine was co\u2010administered. The primary outcome was rapid recovery (meeting all criteria: modified Aldrete score \u22656 at 5 min, \u22659 at 30 min, ambulation \u22653 m at 30 min). Secondary outcomes included sedation success (all: EUS completion, without &gt;2 top\u2010ups within 10 min, without rescue sedation, without agitation requiring interruption), recovery time, flumazenil use, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We analyzed 139 patients (remimazolam,\n                      <jats:italic>n<\/jats:italic>\n                      = 75; midazolam,\n                      <jats:italic>n<\/jats:italic>\n                      = 64). Rapid recovery was more frequent with remimazolam (70.7%\u00a0vs. 25.0%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Sedation success was higher (92.0%\u00a0vs. 73.4%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005), recovery was shorter (median 34\u00a0vs. 55\u00a0min,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), and flumazenil use was lower (4.0%\u00a0vs. 45.3%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Hypoxemia (SpO\n                      <jats:sub>2<\/jats:sub>\n                      &lt;90% lasting \u226510 s) occurred slightly more often with remimazolam (30.6%\u00a0vs. 26.6%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.707), but all episodes were mild and reversible with airway support\/oxygen. Hypotension was rare and comparable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Remimazolam provided faster recovery and higher sedation success than midazolam in outpatient pancreatobiliary EUS. Supplemental oxygen before sedation is a reasonable option to enhance safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70267","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:04:45Z","timestamp":1770264285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and Safety of Remimazolam Compared to Midazolam for Sedation During Endoscopic Ultrasonography: A Single\u2010Center Retrospective Cohort Study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7300-3665","authenticated-orcid":false,"given":"Haruka","family":"Toyonaga","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kansai Medical University Medical Center Osaka 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