{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:59:13Z","timestamp":1790175553917,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Remimazolam is an ultra\u2010short\u2010acting benzodiazepine recently approved for endoscopic procedures in Japan as a sedative agent. We aimed to compare the efficacy and safety of remimazolam and midazolam for endoscopic retrograde cholangiopancreatography (ERCP)\u2010related procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ERCP\u2010related procedures performed under sedation with remimazolam (between August 2025 and November 2025) and midazolam (between April 2025 and July 2025) were retrospectively reviewed. The primary outcome was the time from the end of the procedure to patient awakening and readiness for discharge. The secondary outcomes included sedation success throughout the procedure, time from the initial dose to achieving sedation, dosage, rate of antagonist use for awakening, and sedation\u2010related adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010eight patients underwent ERCP\u2010related procedures with remimazolam and 86 with midazolam. The median times from the end of the procedure to patient awakening and readiness for discharge with remimazolam and midazolam were 2 min (interquartile range [IQR], 1\u20133) and 4 min (IQR, 3\u20135), respectively. Sedation with remimazolam required a shorter time to awaken than sedation with midazolam (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). Furthermore, the rate of antagonist use for awakening was significantly lower with remimazolam than with midazolam (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). The success rate of sedation, median time from the initial dose to achieving sedation, and rate of sedation\u2010related adverse events were not significantly different between groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.49, 0.13, and 0.27, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Remimazolam demonstrated significantly shorter time to patient awakening, suggesting a safer and more efficient discharge process after ERCP\u2010related procedures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70281","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:52:02Z","timestamp":1768297922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Remimazolam and Midazolam for Sedation During Endoscopic Retrograde Cholangiopancreatography\u2010Related Procedures"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-3306","authenticated-orcid":false,"given":"Yuki","family":"Tanisaka","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Saitama Medical University International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shomei","family":"Ryozawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saitama Medical University International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saitama Medical University International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Mizuide","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saitama Medical University International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-0512","authenticated-orcid":false,"given":"Akashi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saitama Medical University International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saitama Medical University International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Hamamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saitama Medical University International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Matsuno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saitama Medical University International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2005.04.015"},{"key":"e_1_2_14_3_1","article-title":"Prospective Assessment of Probe\u2010based Confocal Laser Endomicroscopy Under Direct Cholangioscopic Visualization for Biliary Strictures That Could Not be Definitively Diagnosed Using Endoscopic Retrograde Cholangiopancreatography (With video)","volume":"25","author":"Tanisaka Y.","year":"2024","journal-title":"DEN 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