{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:59:15Z","timestamp":1790175555934,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Although Brunner's glands (BGs), located in the submucosa of the duodenum, may be involved by tumor cells of superficial non\u2010ampullary duodenal epithelial tumors (SNADETs), the detailed incidence and histopathological features have not yet been analyzed. This study aimed to clarify the histopathological relationship between SNADETs and BGs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed SNADETs that were resected at a single center between 2006 and 2021. Resected specimens were histologically evaluated to determine the presence and\/or involvement of SNADET in BGs. The relationship between clinicopathological features and tumor involvement in BGs was also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 114 lesions were included. Direct connection with BGs was seen in 52.6% of SNADETs, and submucosal BG involvement was observed in 7.0% (95% confidence interval 3.1%\u201313.4%) of SNADETs. The presence of submucosal BG involvement was significantly associated with 0\u2010IIc morphology, high\u2010grade dysplasia or carcinoma, and the gastric mucinous phenotype. The presence of either a lesion size 10\u00a0mm or greater or 0\u2010IIc morphology demonstrated a sensitivity of 100%, a specificity of 34.9%, and a false negative rate of 0% for predicting submucosal BG involvement. Moreover, non\u2010neoplastic BGs were exposed at the vertical margin in 15.1% of endoscopic resection specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SNADETs can have submucosal involvement via BGs, particularly in lesions fulfilling either a size \u226510\u00a0mm or a 0\u2010IIc morphology. These pathological findings suggest that vertical resectability may be relevant in their endoscopic management, although further studies are needed to clarify clinical implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70284","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T04:03:30Z","timestamp":1769486610000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological Features of Superficial Non\u2010Ampullary Duodenal Epithelial Tumors Involving Brunner's Glands"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0671-7630","authenticated-orcid":false,"given":"Kazuki","family":"Takayama","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Osaka Medical and Pharmaceutical University  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7721-8292","authenticated-orcid":false,"given":"Taro","family":"Iwatsubo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Osaka Medical and Pharmaceutical University  Takatsuki Japan"},{"name":"Endoscopy Center Osaka Medical and Pharmaceutical University Hospital  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka Medical and Pharmaceutical University  Takatsuki Japan"},{"name":"Division of Pathology Osaka Medical and Pharmaceutical University Hospital  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Osaka Medical and Pharmaceutical University  Takatsuki Japan"},{"name":"Endoscopy Center Osaka Medical and Pharmaceutical University Hospital  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitoshi","family":"Hakoda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Osaka Medical and Pharmaceutical University  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Osaka Medical and Pharmaceutical University  Takatsuki Japan"},{"name":"Endoscopy Center Osaka Medical and Pharmaceutical University Hospital  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Osaka Medical and Pharmaceutical University  Takatsuki Japan"},{"name":"Endoscopy Center Osaka Medical and Pharmaceutical University Hospital  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Osaka Medical and Pharmaceutical University  Takatsuki Japan"},{"name":"Endoscopy Center Osaka Medical and Pharmaceutical University Hospital  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of General and Gastroenterological Surgery Osaka Medical and Pharmaceutical University  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Tomioka","sequence":"additional","affiliation":[{"name":"Department of General and Gastroenterological Surgery Osaka Medical and Pharmaceutical University  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of General and Gastroenterological Surgery Osaka Medical and Pharmaceutical University  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Asakuma","sequence":"additional","affiliation":[{"name":"Department of General and Gastroenterological Surgery Osaka Medical and Pharmaceutical University  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Woong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of General and Gastroenterological Surgery Osaka Medical and Pharmaceutical University  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Osaka Medical and Pharmaceutical University  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka Medical and Pharmaceutical University  Takatsuki Japan"},{"name":"Division of Pathology Osaka Medical and Pharmaceutical University Hospital  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Osaka Medical and Pharmaceutical University  Takatsuki Japan"},{"name":"Endoscopy Center Osaka Medical and Pharmaceutical University Hospital  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.338"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15285"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12277"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-022-01919-y"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-107028"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-124765"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-021-08899-9"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2306-6535"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.12.026"},{"key":"e_1_2_14_11_1","first-page":"154","article-title":"Underwater Endoscopic Mucosal Resection for Superficial Nonampullary Duodenal Adenomas","volume":"50","author":"Yamasaki Y.","year":"2018","journal-title":"Endoscopy"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452363"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.05.002"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00681.x"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-002-0615-z"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000278"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.1.130"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1442-2395"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62668-7"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.10.041"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.01.051"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14824"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000544939"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002634"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15666"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.12.007"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.14514"}],"container-title":["DEN Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.70284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/deo2.70284","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.70284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:59:28Z","timestamp":1790171968000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/deo2.70284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,26]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/deo2.70284"],"URL":"https:\/\/doi.org\/10.1002\/deo2.70284","archive":["Portico"],"relation":{},"ISSN":["2692-4609","2692-4609"],"issn-type":[{"value":"2692-4609","type":"print"},{"value":"2692-4609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,26]]},"assertion":[{"value":"2025-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70284"}}