{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:59:07Z","timestamp":1790175547415,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Transient global amnesia (TGA) after esophagogastroduodenoscopy (EGD) has been described only in case reports. Because sudden\u2010onset amnesia can mimic stroke and other acute central nervous system disorders, TGA requires careful differentiation in the acute setting, and clinicians need to be familiar with this condition. We estimated its incidence after screening EGD and identified associated risk factors in a large single\u2010center cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 420,979 screening EGDs at a single health checkup center (April 2005\u2013March 2025). All EGDs were performed without sedation, using topical pharyngeal anesthesia only. TGA cases were ascertained from the endoscopy adverse\u2010event registry and confirmed. For analyses, three non\u2010TGA controls per TGA case (1:3 ratio) were randomly selected from examinees undergoing EGD on the same calendar date, using same\u2010day matching. Odds ratios (ORs) were estimated using conditional logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TGA occurred in 64 episodes in 63 individuals of 420,979 examinations (0.0152%). In route\u2010specific analyses from April 2008, the transoral route carried a higher risk than the transnasal route (Fisher's exact test\n                      <jats:italic>p<\/jats:italic>\n                      = 0.013). In multivariable matched models, older age (odds ratio [OR] 2.32 per 10\u2010year increase; 95% confidence interval [CI], 1.38\u20133.92), female sex (14.6; 4.82\u201343.9), transoral insertion (10.2; 1.88\u201355.4), and treated dyslipidemia (2.84; 1.20\u20136.73) were statistically associated. EGD time and endoscopist experience were not associated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The incidence of post\u2010EGD TGA was very low at 15.2 per 100,000 examinations (0.0152%). Older age, female sex, transoral insertion, and treated dyslipidemia were independently associated with post\u2010EGD TGA. A transnasal approach might be a potential risk\u2010reduction strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70298","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T15:26:09Z","timestamp":1770737169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transient Global Amnesia After Screening Esophagogastroduodenoscopy: Incidence and Risk Factors in a 20\u2010Year Single\u2010Center Cohort"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3789-0700","authenticated-orcid":false,"given":"Miyuki","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Yamanashi Koseiren Health Care Center Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Takayama","sequence":"additional","affiliation":[{"name":"Yamanashi Koseiren Health Care Center Yamanashi Japan"},{"name":"Health Care Center University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Ohtaka","sequence":"additional","affiliation":[{"name":"Yamanashi Koseiren Health Care Center Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Yamanashi Koseiren Health Care Center Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hihara","sequence":"additional","affiliation":[{"name":"Yamanashi Koseiren Health Care Center Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Miura","sequence":"additional","affiliation":[{"name":"Yamanashi Koseiren Health Care Center Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hosoda","sequence":"additional","affiliation":[{"name":"Yamanashi Koseiren Health Care Center Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Hirose","sequence":"additional","affiliation":[{"name":"Yamanashi Koseiren Health Care Center Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Takaso","sequence":"additional","affiliation":[{"name":"Yamanashi Koseiren Health Care Center Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshioki","family":"Yoda","sequence":"additional","affiliation":[{"name":"Yamanashi Koseiren Health Care Center Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumikazu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Neurology Koshu Rehabilitation Hospital Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Yokomichi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Environmental Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Faculty of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.53.10.834"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42466\u2010023\u201000240\u20100"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.11280\/gee1973b.32.589"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.11280\/gee1973b.48.1215"},{"key":"e_1_2_14_6_1","first-page":"29","article-title":"Transient Global Amnesia After Upper Gastrointestinal Endoscopy: A Case Report","volume":"24","author":"Naka H.","year":"1997","journal-title":"Medical Journal of Hokkaido Association of Medical Service for Workers"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.11641\/pde.60.2_44"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.087775"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SGA.0b013e3181b90111"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.11404\/jsgcs.24021"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102016\u2010216645"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl105"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354023"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268\u2010024\u201000474\u20106"}],"container-title":["DEN 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