{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:42:14Z","timestamp":1777351334907,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K10340"],"award-info":[{"award-number":["24K10340"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2027,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010endoscopic retrograde cholangiopancreatography (post\u2010ERCP) pancreatitis (PEP) is the most severe adverse event associated with ERCP. Although numerous studies have identified risk factors for PEP, the role of genetic background in its development remains unexplored. The present study investigated the association between pancreatitis\u2010related gene variants (PRG\u2010variants) and PEP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective, single\u2010center study included 94 patients with na\u00efve papilla who underwent ERCP between October 2021 and August 2023. Targeted sequencing was performed to analyze variants in four PRGs:\n                      <jats:italic>PRSS1<\/jats:italic>\n                      ,\n                      <jats:italic>SPINK1<\/jats:italic>\n                      ,\n                      <jats:italic>CTRC<\/jats:italic>\n                      , and\n                      <jats:italic>CPA1<\/jats:italic>\n                      . Patients were classified into two groups based on the presence or absence of PRG\u2010variants, and the incidences of PEP and of post\u2010ERCP hyperpancreatic enzymemia (PEH) were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PRG\u2010variants, regardless of their pathogenicity, were identified in 16 (17%) patients. Among all cases, PEP occurred in four (4%) patients, and PEH occurred in 27 (29%) patients. The incidence of PEP did not differ significantly with and without PRG\u2010variants (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.532). However, the group with PRG\u2010variants had a significantly higher incidence of PEH, as demonstrated by both univariate (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.013) and multivariate analyses (odds ratio, 6.291; 95% confidence interval, 1.133\u201334.934).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present pilot study suggests that patients with PRG\u2010variants, regardless of their pathogenicity, demonstrated a significantly higher incidence of PEH but not PEP. PEH may reflect pancreatic parenchyma injury and may progress to PEP when additional factors are present. Thus, PRG\u2010variants may contribute to biochemical pancreatic injury after ERCP. Further large\u2010scale studies and comprehensive genomic profiling of patients with PEH\/PEP are warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The central ethics committee approved the study protocol (M21\u20100066).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70320","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:14:39Z","timestamp":1777349679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patients With Pancreatitis\u2010Related Gene Variants Showed Higher Incidence of Hyperpancreatic Enzymemia After Endoscopic Retrograde Cholangiopancreatography"],"prefix":"10.1002","volume":"7","author":[{"given":"Daishi","family":"Kabemura","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Graduate School 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