{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:07:15Z","timestamp":1784228835697,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2027,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Small bowel capsule endoscopy (CE) produces lengthy videos that are time\u2010consuming to review and susceptible to missed lesions. We evaluated whether an open\u2010source, pretrained artificial intelligence (AI) model (SEE\u2010AI) could improve diagnostic performance and interpretation efficiency compared with conventional reading.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 249 PillCam SB3 examinations performed between 2007 and 2022 at six hospitals, using a two\u2010reader crossover design. SEE\u2010AI (confidence threshold 0.1) generated annotated videos with bounding boxes for eight lesion categories. The primary endpoints were sensitivity for lesion detection on a per\u2010lesion and per\u2010patient basis. Secondary endpoints included specificity, predictive values, overall accuracy, and reading time. A prespecified subgroup analysis evaluated cases of suspected small\u2010bowel bleeding (SSBB), focusing on Saurin P1+P2 hemorrhagic lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Across 1550 adjudicated lesions, AI\u2010assisted reading demonstrated higher sensitivity than conventional reading (per\u2010lesion: 98.8% [1532\/1550] vs. 86.4% [1339\/1550]; per\u2010patient: 99.1% [464\/468] vs. 80.3% [376\/468]; both\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001). The mean reading time decreased from 17.9 to 13.7 min (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001). In SSBB cases (\n                      <jats:italic>n<\/jats:italic>\n                      = 131), sensitivity for P1+P2 lesions improved on both a per\u2010lesion basis (98.2% [439\/447] vs. 82.8% [370\/447]) and per\u2010patient basis (98.6% [145\/147] vs. 73.5% [108\/147]), with a shorter reading time (14.1\u00a0vs. 18.0 min; all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this multicenter evaluation, SEE\u2010AI significantly improved lesion detection and reduced reading time for CE interpretation, including SSBB cases, while maintaining openness and reproducibility. AI\u2010assisted reading may reduce clinicians\u2019 workload and support the adoption of SEE\u2010AI as a practical tool \u2015 and a potential future standard of care \u2015 for small bowel CE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>N\/A.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70346","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:43:59Z","timestamp":1778849039000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Improved Efficiency and Lesion Detection in Small Bowel Capsule Endoscopy Using the Open\u2010Source Artificial Intelligence Model SEE\u2010AI"],"prefix":"10.1002","volume":"7","author":[{"given":"Satoshi","family":"Miyazono","sequence":"first","affiliation":[{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Umeno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Nagasue","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Department of Endoscopic Diagnostics and Therapeutics Kyushu University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuto","family":"Saiki","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University  Fukuoka 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University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaro","family":"Ihara","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Matsuno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Imazu","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"International Medical Department Kyushu University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Nashaat","family":"Mohamed","sequence":"additional","affiliation":[{"name":"The National Hepatology and Tropical Medicine Research Institute  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Fukuoka Red Cross Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Yamagata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hamanomachi Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Kurahara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Matsuyama Red Cross Hospital Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Yada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Onga Nakama Medical Association, Onga Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Harada","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yamaguchi Red Cross Hospital  Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Ago","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University  Fukuoka 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