{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:08:29Z","timestamp":1784228909518,"version":"3.55.0"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2027,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A 59\u2010year\u2010old man with a history of colorectal polypectomy underwent a screening colonoscopy. A 5\u2010mm reddish lesion was identified in the sigmoid colon. The lesion had a smooth surface without erosion or ulceration and appeared slightly elevated with well\u2010demarcated margins. Magnifying narrow\u2010band imaging revealed dilated round pits, reduced crypt density, and arborizing vessels in the central area. Cold snare polypectomy was performed for diagnostic and therapeutic purposes. Histopathological examination demonstrated proliferation of bland spindle cells with oval nuclei in the lamina propria. Immunohistochemistry showed positivity for vimentin and GLUT\u20101, weak epithelial membrane antigen expression, and negativity for S\u2010100, SMA, c\u2010kit, and CD34, with a Ki\u201067 index of &lt;1%. These findings were consistent with colonic perineurioma, a rare benign peripheral nerve sheath tumor composed of perineurial cells. This case highlights that colonic perineurioma should be considered in the differential diagnosis of small subepithelial lesions detected during colonoscopy. Reduced crypt density and arborizing vessels may provide subtle clues; however, definitive diagnosis requires histopathological and immunohistochemical evaluation.<\/jats:p>","DOI":"10.1002\/deo2.70361","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:17:16Z","timestamp":1781072236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Colonic Perineurioma Presenting as a Small Subepithelial Lesion With Distinctive Endoscopic Findings"],"prefix":"10.1002","volume":"7","author":[{"given":"Hironobu","family":"Takedomi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Gastroenterology Faculty of Medicine Saga University  Saga Japan"},{"name":"Department of Gastroenterology Hiramatsu Hospital Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moeko","family":"Shirozu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hiramatsu Hospital Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hiramatsu Hospital Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Esaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Gastroenterology Faculty of Medicine Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000154130.87219.2c"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/crgm\/1636142"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-227170"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200403000-00010"},{"key":"e_1_2_10_6_1","first-page":"812","article-title":"Perineurioma","volume":"52","author":"Murakami T.","year":"2017","journal-title":"Stomach and Intestine"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-014-0519-x"},{"key":"e_1_2_10_8_1","article-title":"Epithelial\u2010Stromal Polyp With Features of Perineurioma Lacking Covering Serrated Crypts Associated With a Sessile Serrated Lesion With High\u2010Grade Dysplasia of the Colon: A Case Report","volume":"17","author":"Mori H.","year":"2025","journal-title":"Cureus"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181f4a458"}],"container-title":["DEN Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.70361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/deo2.70361","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.70361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:47:37Z","timestamp":1784227657000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/deo2.70361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,4]]}},"alternative-id":["10.1002\/deo2.70361"],"URL":"https:\/\/doi.org\/10.1002\/deo2.70361","archive":["Portico"],"relation":{},"ISSN":["2692-4609","2692-4609"],"issn-type":[{"value":"2692-4609","type":"print"},{"value":"2692-4609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]},"assertion":[{"value":"2026-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70361"}}