{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:19:17Z","timestamp":1787635157971,"version":"build-2736575974"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2027,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Colonic adenomatous polyposis is most commonly caused by germline pathogenic variants in the\n                    <jats:italic>APC<\/jats:italic>\n                    gene; however, recent genetic studies have identified patients without\n                    <jats:italic>APC<\/jats:italic>\n                    mutations.\n                    <jats:italic>AXIN2<\/jats:italic>\n                    \u2010associated colonic polyposis is a rare condition related to dysregulation of the Wnt\/\u03b2\u2010catenin signaling pathway. Most reported cases have involved germline\n                    <jats:italic>AXIN2<\/jats:italic>\n                    variants, whereas somatic mosaic\n                    <jats:italic>AXIN2<\/jats:italic>\n                    alterations remain poorly documented. We report a rare case of somatic mosaic\n                    <jats:italic>AXIN2<\/jats:italic>\n                    \u2010associated colonic polyposis predominantly involving the proximal colon. A 77\u2010year\u2010old asymptomatic man was referred for colonoscopic surveillance after previous polypectomy. Colonoscopy revealed multiple adenomatous polyps from the cecum to the proximal ascending colon, with some lesions up to 10\u00a0mm in size, while only a few small polyps were observed in the transverse and descending colon and none in the sigmoid colon or rectum. The patient underwent intensive endoscopic management, including endoscopic submucosal dissection for extensive adenomatous mucosa in the cecum, followed by repeated endoscopic resections and close surveillance. Histopathological examination confirmed low\u2010grade tubular adenomas. Because of multiple adenomas, genetic testing was performed after genetic counseling. No pathogenic variants were detected in peripheral blood. Analysis of independently resected colonic polyps consistently identified the same heterozygous frameshift mutation in\n                    <jats:italic>AXIN2<\/jats:italic>\n                    with loss of heterozygosity, whereas no\n                    <jats:italic>AXIN2<\/jats:italic>\n                    abnormalities were detected in normal colonic mucosa, leading to a definitive diagnosis of somatic mosaic\n                    <jats:italic>AXIN2<\/jats:italic>\n                    \u2010associated colonic polyposis. This case highlights a previously unreported mechanism of\n                    <jats:italic>AXIN2<\/jats:italic>\n                    \u2010driven colonic polyposis through somatic mosaicism and suggests that intensive endoscopic treatment with close surveillance may be an effective management strategy in selected patients.\n                  <\/jats:p>","DOI":"10.1002\/deo2.70409","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:37:11Z","timestamp":1787632631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Somatic Mosaic\n                    <i>AXIN2<\/i>\n                    \u2010associated Colonic Polyposis Predominantly Involving the Proximal Colon: A Case Report"],"prefix":"10.1002","volume":"7","author":[{"given":"Takashi","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Graduate School of Medicine Juntendo University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Diagnostics and Therapeutics of Intractable Diseases Intractable Disease Research Center Graduate School of Medicine Juntendo University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Hirasawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University Faculty of Medicine  Tokyo 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Nagahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University Faculty of Medicine  Tokyo Japan"},{"name":"Department of Pathophysiological Research and Therapeutics for Gastrointestinal Disease Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0092-8674(81)90021-0","article-title":"Identification and Characterization of the Familial Adenomatous Polyposis Coli Gene","volume":"66","author":"Groden J.","year":"1991","journal-title":"Cell"},{"issue":"6","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2\u2010catenin Signaling and 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