{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:14:45Z","timestamp":1788448485411,"version":"build-2803163510"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2027,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Esophageal varices are a common complication of portal hypertension, and prophylactic endoscopic injection sclerotherapy with ligation (EISL) is an established treatment option. Effective variceal thrombosis requires sufficient intravariceal retention of the sclerosant, because ethanolamine oleate exerts its thrombogenic effect through prolonged contact with the venous endothelium. In conventional EISL, endoscopic variceal ligation (EVL) is performed after balloon deflation, leaving a transient interval during which restored blood flow and an open puncture site may permit washout of the sclerosant and bleeding. We describe EIS with pre\u2010deflation ligation (EISpdL), in which EVL of the puncture site is completed while the endoscope balloon remains inflated, and balloon compression is maintained throughout the retention period. A 59\u2010year\u2010old man with medium\u2010sized esophageal varices with a positive red color sign (F2, RC1) secondary to metabolic dysfunction\u2010associated steatohepatitis underwent EISpdL combined with gel\u2010immersion EIS. The procedure was technically feasible, required no additional skills beyond conventional EISL, and no immediate procedure\u2010related adverse events were observed. Follow\u2010up endoscopy on post\u2010procedure day 7 showed bronze\u2010colored variceal changes indicating thrombosis, and contrast\u2010enhanced computed tomography two months later confirmed obliteration. EISpdL may enable more stable and prolonged sclerosant retention.<\/jats:p>","DOI":"10.1002\/deo2.70410","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:20:44Z","timestamp":1788445244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic Injection Sclerotherapy With Pre\u2010deflation Ligation for Prolonged Sclerosant Retention in Esophageal Varices: A Case Report"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6508-6525","authenticated-orcid":false,"given":"Noriaki","family":"Sugawara","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7721-8292","authenticated-orcid":false,"given":"Taro","family":"Iwatsubo","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9929-5616","authenticated-orcid":false,"given":"Masatoshi","family":"Kaizuka","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka 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Pharmaceutical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5628-9662","authenticated-orcid":false,"given":"Kazuhiro","family":"Ota","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0488-3297","authenticated-orcid":false,"given":"Hiroki","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2305\u20105839.2014.05.02"},{"key":"e_1_2_10_3_1","first-page":"733","article-title":"Endoscopic Injection Sclerotherapy With Ligation versus Endoscopic Injection Sclerotherapy Alone in the Management of Esophageal Varices: A Prospective Randomized Trial","volume":"47","author":"Shigemitsu T.","year":"2000","journal-title":"Hepato\u2010Gastroenterology"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/deo2.70313"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf02776821"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102114\u20100131"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/deo2.70056"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/deo2.70201"},{"key":"e_1_2_10_9_1","first-page":"79","article-title":"Mechanisms of Action and Therapeutic Outcomes of Various Sclerosing Agents: Ethanolamine Oleate (EO)","volume":"6","author":"Obara K.","year":"1991","journal-title":"Rinsho Shokakinaika"}],"container-title":["DEN 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