{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:06:20Z","timestamp":1789635980904,"version":"4.0.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2027,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Endoscopic submucosal dissection (ESD) has become an established therapeutic approach for duodenal adenomas, although it is technically demanding. Duodenal mucosal resurfacing (DMR) is an emerging endoscopic metabolic therapy designed to ablate and regenerate duodenal mucosa. To date, no reports have described ESD including the papilla (ESDIP) producing similar metabolic effects to DMR. A 36\u2010year\u2010old Asian man with an elevated body mass index of 30.16\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    was diagnosed with a large duodenal laterally spreading tumor, measuring 80\u00a0\u00d7\u00a070\u00a0mm in size and extending to the major papilla. Water\u2010pressure method\u2010assisted ESDIP was performed with en bloc resection, and histopathology demonstrated a tubulovillous adenoma with low\u2010grade dysplasia and uninvolved margins. Remarkably, during the 2\u2010 and 8\u2010week follow\u2010up periods, the patient exhibited reductions in total body weight of 5.9% and 7.9%, respectively, and a marked improvement in glycemic control, with fasting blood glucose decreasing from 210 to 113\u00a0mg\/dL despite no changes in lifestyle or medication. These metabolic improvements suggest a possible clinical overlap between extensive duodenal mucosal resection via ESDIP and DMR. However, given the limitations of a single case, these findings warrant cautious interpretation and further study to clarify the underlying mechanisms.\n                  <\/jats:p>","DOI":"10.1002\/deo2.70433","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:51:37Z","timestamp":1789635097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic Improvement and Weight Reduction After Large Endoscopic Submucosal Dissection Including the Papilla for Duodenal Adenoma: A Case Report"],"prefix":"10.1002","volume":"7","author":[{"given":"Chi\u2010Chu","family":"Lo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Gastroenterology and Hepatology, Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Shuan","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Gastroenterology and Hepatology, Far Eastern Memorial Hospital  New Taipei City Taiwan"},{"name":"Department of Electrical Engineering, Yuan Ze University  Taoyuan Taiwan"},{"name":"Taiwan Association for the Study of Intestinal Diseases (TASID)  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Wei","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Gastroenterology and Hepatology, Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Chen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurato","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Center For Diagnostic and Therapeutic Endoscopy Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiko","family":"Kato","sequence":"additional","affiliation":[{"name":"Center For Diagnostic and Therapeutic Endoscopy Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S2213-8587(24)00316-4","article-title":"Definition and Diagnostic Criteria of Clinical Obesity","volume":"13","author":"Rubino F.","year":"2025","journal-title":"Lancet Diabetes & Endocrinology"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2022.109194","article-title":"Durable Metabolic Improvements 2 Years After Duodenal Mucosal Resurfacing (DMR) in Patients With Type 2 Diabetes (REVITA\u20101 Study)","volume":"184","author":"Baar A. C. G.","year":"2022","journal-title":"Diabetes Research and Clinical Practice"},{"issue":"2","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1136\/gutjnl-2020-323608","article-title":"Safety and Efficacy of Hydrothermal Duodenal Mucosal Resurfacing in Patients With Type 2 Diabetes: The Randomised, Double\u2010blind, Sham\u2010controlled, Multicentre REVITA\u20102 Feasibility Trial","volume":"71","author":"Mingrone G.","year":"2022","journal-title":"Gut"},{"issue":"5","key":"e_1_2_10_5_1","first-page":"522","article-title":"Endoscopic Management of Superficial Nonampullary Duodenal Tumors","volume":"53","author":"Vanbiervliet G.","year":"2021","journal-title":"European Society of Gastrointestinal Endoscopy (ESGE) Guideline Endoscopy"},{"issue":"10481","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(25)00355-1","article-title":"Global, regional, and national prevalence of adult overweight and obesity, 1990\u20132021, with forecasts to 2050: A forecasting study for the Global Burden of Disease Study 2021","volume":"405","author":"Ng M.","year":"2025","journal-title":"Lancet"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev-med-043021-014919","article-title":"New Frontiers in Obesity Treatment: GLP\u20101 and Nascent Nutrient\u2010Stimulated Hormone\u2010Based Therapeutics","volume":"74","author":"Jastreboff A. M.","year":"2023","journal-title":"Annual Review of Medicine"},{"issue":"7","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1053\/j.gastro.2017.01.044","article-title":"Endoscopic Bariatric and Metabolic Therapies: New and Emerging Technologies","volume":"152","author":"Sullivan S.","year":"2017","journal-title":"Gastroenterology"},{"issue":"3","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1159\/000547461","article-title":"Current Management of Duodenal Neoplasia: Endoscopic Treatment for Large Superficial Non\u2010Ampullary Duodenal Epithelial Tumor","volume":"107","author":"Miyazaki K.","year":"2026","journal-title":"Digestion"},{"issue":"4","key":"e_1_2_10_10_1","first-page":"429","article-title":"Endoscopic Management of Ampullary Tumors","volume":"53","author":"Vanbiervliet G.","year":"2021","journal-title":"European Society of Gastrointestinal Endoscopy (ESGE) Guideline Endoscopy"},{"issue":"4","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/den.14942","article-title":"Feasibility of Endoscopic Submucosal Dissection Including Papilla (With Video)","volume":"37","author":"Yahagi N.","year":"2025","journal-title":"Digestive Endoscopy"}],"container-title":["DEN Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.70433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/deo2.70433","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.70433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:51:39Z","timestamp":1789635099000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/deo2.70433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,4]]}},"alternative-id":["10.1002\/deo2.70433"],"URL":"https:\/\/doi.org\/10.1002\/deo2.70433","archive":["Portico"],"relation":{},"ISSN":["2692-4609","2692-4609"],"issn-type":[{"value":"2692-4609","type":"print"},{"value":"2692-4609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]},"assertion":[{"value":"2026-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70433"}}