{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:05:34Z","timestamp":1790157934306,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2027,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate early changes in gastric cancers that are difficult to evaluate using endoscopic imaging through the assessment of mucosal impedance (MI) in endoscopic submucosal dissection (ESD) specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010center prospective cohort study, we included patients who underwent ESD for early gastric cancer (EGC). MI was measured at both the main tumor site and the surrounding non\u2010neoplastic mucosa in resected specimens. Histopathological evaluation and immunohistochemical staining for claudin\u20103, \u20104, and \u201018 were performed. Furthermore, multivariate analysis was used to investigate factors influencing MI\u2010L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The MI measured under high\u2010frequency current (MI\u2010H) of the non\u2010neoplastic mucosa was significantly higher than that of the tumor (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0025). Additionally, the MI measured under low\u2010frequency current (MI\u2010L) was significantly lower in pT1b cases than in pT1a cases (6.9 \u03a9 vs. 9.7 \u03a9,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.021). Similarly, the MI\u2010L was significantly lower in the pUL1 cases than in the pUL0 cases (7.5 \u03a9 vs. 9.7 \u03a9,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.030). Multivariable linear regression analysis demonstrated that, among the explanatory variables\u2014including tumor invasion, ulcer status, macroscopic type, and the H\u2010scores for each claudin\u2010 only the H\u2010score of claudin\u201018 was identified as an independent associated factor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In resected specimens, MI\u2010L was independently associated with claudin\u201018 expression and correlated with submucosal invasion, ulcer status, and macroscopic type. MI has the potential to detect non\u2010surface changes involving tight junction proteins in EGC that cannot be observed via endoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:bold>Trial Registration<\/jats:bold>\n                      : N\/A.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70434","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:16:01Z","timestamp":1790154961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Submucosal Invasion and Ulceration in Early Gastric Cancer Affect Mucosal Impedance"],"prefix":"10.1002","volume":"7","author":[{"given":"Kaede","family":"Miyashiro","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hematology, and Clinical Immunology Hirosaki University Graduate School of Medicine  Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hematology, and Clinical Immunology Hirosaki University Graduate School of Medicine  Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidezumi","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hematology, and Clinical Immunology Hirosaki University Graduate School of Medicine  Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Hirosaki University Graduate School of Medicine  Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Hirosaki University Graduate School of Medicine  Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hematology, and Clinical Immunology Hirosaki University Graduate School of Medicine  Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taka","family":"Asari","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hematology, and Clinical Immunology Hirosaki University Graduate School of Medicine  Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuta","family":"Tetsuya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hematology, and Clinical Immunology Hirosaki University Graduate School of Medicine  Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Chinda","sequence":"additional","affiliation":[{"name":"Division of Endoscopy Hirosaki University Hospital  Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotake","family":"Sakuraba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hematology, and Clinical Immunology Hirosaki University Graduate School of Medicine  Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mex.2024.103087"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs\u201021\u2010348"},{"key":"e_1_2_10_4_1","article-title":"The Accuracy of Electrical Impedance Tomography for Breast Cancer Detection: A Systematic Review and Meta\u2010Analysis","volume":"26","author":"Rezanejad Gatabi 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