{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:04:20Z","timestamp":1789617860979,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2027,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Studies of non\u2010anesthesiologist\u2010administered propofol (NAAP) during colorectal endoscopic submucosal dissection (ESD) are scarce, particularly in the elderly. We evaluated its feasibility across a broad age range and identified factors associated with sedation\u2010related adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 454 consecutive colorectal ESD procedures performed with NAAP in 405 patients at a tertiary center (January 2016\u2013May 2024), stratified by age (&lt;65, 65\u201374, and \u226575 years). Propofol was given by the endoscopy team as a weight\u2010based induction bolus and a continuous infusion titrated to target depth under multiparameter monitoring. New\u2010onset hypotension, bradycardia, and hypoxemia were compared among groups, with multivariable logistic regression for independent predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean age was 68.2 years; 54.8% of procedures were performed in men. Adverse events were common but all transient: hypotension 14.1%, bradycardia 14.8%, hypoxemia 11.9%, without procedure discontinuation, intubation, anesthesiologist rescue, death, or permanent sequelae. A composite event (33.3%) rose with age (24.7%, 36.1%, and 39.1%;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.018). In multivariable analysis, longer procedure duration, measured as propofol administration time, was independently associated with composite events (adjusted odds ratio [aOR] 1.05 per 10\u00a0min;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.011) and bradycardia (aOR 1.07 per 10\u00a0min;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002). Age \u226575 years (vs. &lt;65 years) was independently associated with composite events (aOR 1.85;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.027) and hypoxemia (aOR 2.55;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.021).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Propofol\u2010based NAAP allowed colorectal ESD to be completed across all age groups without sedation\u2010related procedure termination or escalation of care. Older age and longer procedure duration were associated with selected sedation\u2010related adverse events, providing clinically relevant information for risk assessment during colorectal ESD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>N\/A.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70435","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:32:56Z","timestamp":1789615976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility and Safety Profile of Non\u2010anesthesiologist\u2010administered Propofol During Colorectal Endoscopic Submucosal Dissection: A Single\u2010center Study of 454 Procedures"],"prefix":"10.1002","volume":"7","author":[{"given":"Yumi","family":"Kishi","sequence":"first","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayo","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Uragami","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daijiro","family":"Shiomi","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Kurahashi","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Hanzawa","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michimasa","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Muraoka","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatsuka","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Miyake","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Okada","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Toshimori","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa Medical University Koto Toyosu Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13545"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101811\u20107025"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13882"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010018\u20100672\u20103"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053311"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.12.047"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i26.3420"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.06.025"},{"issue":"3","key":"e_1_2_12_10_1","first-page":"259","article-title":"Endoscopist\u2010administered Propofol Sedation is Safe\u2014A Prospective Evaluation of 10,000 Patients in an Outpatient Practice","volume":"21","author":"Friedrich K.","year":"2012","journal-title":"Journal of Gastrointestinal and Liver Diseases"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/deo2.70025"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.07.018"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102898\u20106540"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102023\u2010330396"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2010.04352.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4627"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i34.11985"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619831126"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12342"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5937426"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12457"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101306776"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010017\u20101358\u20106"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100043\u2010122225"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500874"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120\u2010013\u20100336\u20109"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41424\u2010018\u20100032\u20105"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/deo2.223"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2107138"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2018.07.005"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010020\u201001299\u20108"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.15030"}],"container-title":["DEN Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.70435","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/deo2.70435","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/deo2.70435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:32:59Z","timestamp":1789615979000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/deo2.70435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,4]]}},"alternative-id":["10.1002\/deo2.70435"],"URL":"https:\/\/doi.org\/10.1002\/deo2.70435","archive":["Portico"],"relation":{},"ISSN":["2692-4609","2692-4609"],"issn-type":[{"value":"2692-4609","type":"print"},{"value":"2692-4609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]},"assertion":[{"value":"2026-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70435"}}