{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:50:36Z","timestamp":1791370236032,"version":"4.3.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2027,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n Gel immersion can provide a stable immersion environment during endoscopic mucosal resection (EMR). However, its application in superficial esophageal squamous lesions remains limited. In this study, we evaluated a gel immersion EMR (GI\u2010EMR) technique in which submucosal injection was intentionally performed before snaring for selected small superficial esophageal squamous lesions.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This single\u2010center, retrospective case series included consecutive patients who underwent GI\u2010EMR with submucosal injection for superficial esophageal squamous lesions \u226415\u00a0mm in size between January and March 2026. The primary outcome was the histological en bloc resection rate, while secondary outcomes included technical success, endoscopic en bloc resection rate, procedure time, adverse events, and histopathological findings.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n GI\u2010EMR with submucosal injection was attempted for 13 lesions, achieving a technical success rate of 92% (12\/13). One procedure was discontinued because adequate lifting could not be achieved due to post\u2010chemoradiotherapy scarring. The endoscopic and histological en bloc resection rates were both 85% (11\/13) on an intention\u2010to\u2010treat basis. The median procedure time was 4.25 min (range, 2.0\u201311.0\u00a0min). No intraoperative or delayed perforation, post\u2010procedure bleeding, or gel\u2010related adverse events occurred.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n GI\u2010EMR with submucosal injection was technically feasible for selected superficial esophageal squamous lesions \u226415\u00a0mm, with no serious procedure\u2010related adverse events observed in this small case series.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n N\/A<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/deo2.70444","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:02:03Z","timestamp":1791367323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gel Immersion Endoscopic Mucosal Resection With Submucosal Injection for Superficial Esophageal Squamous Neoplasms (With Video)"],"prefix":"10.1002","volume":"7","author":[{"given":"Takahiro","family":"Uda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0942-1541","authenticated-orcid":false,"given":"Yuji","family":"Urabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Gurita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Hatsushika","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Sako","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1166-8201","authenticated-orcid":false,"given":"Yuichi","family":"Hiyama","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Center Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5068-6990","authenticated-orcid":false,"given":"Yoshihiro","family":"Kishida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6369-0641","authenticated-orcid":false,"given":"Hidehiko","family":"Takigawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1528-1939","authenticated-orcid":false,"given":"Akira","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9956-1358","authenticated-orcid":false,"given":"Toshio","family":"Kuwai","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Endoscopy and Medicine Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8266-3235","authenticated-orcid":false,"given":"Shinji","family":"Mii","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-0743","authenticated-orcid":false,"given":"Shiro","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University 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