{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:39:06Z","timestamp":1792589946435,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["DEN Open"],"published-print":{"date-parts":[[2027,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Although endoscopic resection is widely performed for superficial non\u2010ampullary duodenal epithelial tumors (SNADETs), conventional endoscopic mucosal resection (CEMR) may be associated with suboptimal complete resection rates. Partial injection underwater EMR (PI\u2010UEMR) has been proposed to improve the visualization of distal lesion margins and facilitate en bloc resection. We aimed to evaluate the outcomes of PI\u2010UEMR for SNADETs, using CEMR as a historical institutional comparator.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center observational cohort study included patients who underwent endoscopic mucosal resection for SNADETs between September 2015 and December 2025. Lesions treated with CEMR or PI\u2010UEMR were analyzed. The primary outcomes were en bloc and R0 resection rates. The secondary outcomes included histological diagnosis and procedure\u2010related adverse events, including intraoperative perforation, delayed perforation, and delayed bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 77 lesions in 73 patients were analyzed, including 39 treated with CEMR and 38 treated with PI\u2010UEMR. The en bloc resection rates were 90.0% and 97.4% in the CEMR and PI\u2010UEMR groups, respectively. The R0 resection rate was significantly higher in the PI\u2010UEMR group than in the CEMR group (89.4% vs. 69.2%). Histological diagnoses were similar between the groups. No intraoperative perforation occurred in either group. No procedure\u2010related adverse events, including delayed perforation or bleeding, were observed in the PI\u2010UEMR group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While maintaining a favorable safety profile, PI\u2010UEMR was associated with a higher R0 resection rate than CEMR in this study. It may represent an effective endoscopic treatment option for SNADETs, particularly when precise visualization of the distal lesion margins is required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:bold>Trial Registration<\/jats:bold>\n                      : University Hospital Medical Information Network: UMIN000060637\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/deo2.70453","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:45:32Z","timestamp":1792586732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Partial Injection Underwater Endoscopic Mucosal Resection for Superficial Non\u2010ampullary Duodenal Epithelial Tumors (With Video)"],"prefix":"10.1002","volume":"7","author":[{"given":"Noboru","family":"Misawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Higurashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kojiro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City University School of Medicine Kanagawa 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