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Experiment 1 showed that interactions with intoxicated siblings in the home cage on postnatal Days (PD) 12, 14, and 16 results in increased voluntary intake of ethanol when subjects are tested 24 hr after the final exposure. The results also suggested that the endogenous opioid system is not involved in acquisition. Administration of naloxone during social exposure to ethanol had no effect on later ethanol intake. Experiment 2 examined the effects of receptor\u2010selective antagonists administered prior to test. For subjects that had social exposure to ethanol, intake of ethanol was completely suppressed by either naloxone or the \u03b4 antagonist naltrindole. For ethanol\u2010na\u00efve subjects, intake also was completely suppressed by naloxone. However, intake was partially blocked by naltrindole or the \u03bc antagonist \u03b2\u2010FNA. Experiment 3 confirmed the differential involvement of \u03bc and \u03b4 receptors in ethanol intake through a more comprehensive dose\u2013response analysis of \u03b2\u2010FNA and naltrindole. Collectively, these data reveal that learning about ethanol from intoxicated conspecifics not only affects voluntary intake of ethanol but also alters the opioidergic response to ethanol consumption. \u00a9 2004 Wiley Periodicals, Inc. 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