{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:34:42Z","timestamp":1790775282164,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T00:00:00Z","timestamp":1174521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Environmental stimuli in early life may result in permanent behavioral and physiological changes. Present study evaluated the effects of exposing pups to a novel environment on behaviors (open\u2010field test and sexual behavior) and prolactin stress\u2010responses in adult male rats. Half of a litter was daily removed outside (OUT) from the nest and stimulated by handling for 3 min, while the other half remained inside (IN) the nest and was also handled for the same period during the first 10 days postpartum. Maternal behavior after all the pups were returned to the nest was not different between IN and OUT littermates. In adulthood, OUT males showed increased general and central locomotion activity in the open\u2010field test, reduced sexual behavior, and attenuated prolactin secretion in response to restraint stress compared with the IN littermates. The repeated exposition of rat pups to a novel environment is a causal factor for the long\u2010lasting behavioral and endocrine changes. The premature exposition of the pup to unfamiliar environments decreases fear and stress\u2010response, and also reduces sexual behavior. We suggest that the absence of the odor of the mother may be crucial to explain the effects detected in adulthood. \u00a9 2007 Wiley Periodicals, Inc. Dev Psychobiol 49: 258\u2013264, 2007.<\/jats:p>","DOI":"10.1002\/dev.20181","type":"journal-article","created":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T21:37:31Z","timestamp":1174599451000},"page":"258-264","source":"Crossref","is-referenced-by-count":42,"title":["Effects of neonatal novelty exposure on sexual behavior, fear, and stress\u2010response in adult rats"],"prefix":"10.1002","volume":"49","author":[{"given":"Fernando","family":"Benetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Andrade de Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Luiz Sanvitto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo Bolten","family":"Lucion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1385-299X(96)00036-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02725"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(87)90016-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.022"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(03)00149-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(91)90546-Z"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(99)00011-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)80016-6"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(00)00012-2"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(97)00143-5"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1974.36.3.391"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.10095"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)00998-7"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480231012"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.135.3506.795-a"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(67)90011-X"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5332.1659"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03541.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(85)90183-X"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1999.00409.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000134988.51310.c3"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4578-03.2004"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20093"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(96)00225-9"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.115.6.1332"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(93)90189-V"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.115.1.71"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300125"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.02.019"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(86)90256-7"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.58203"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1523\/JNEUROSCI.09-11-03998.1989","article-title":"Norepinephrine and learning\u2010induced plasticity in infant rat olfactory system","volume":"9","author":"Sullivan R. 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