{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:20:14Z","timestamp":1791400814921,"version":"4.3.3"},"reference-count":69,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,6,12]],"date-time":"2008-06-12T00:00:00Z","timestamp":1213228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was designed to further assess cognitive and affective functioning in a mouse model of Fragile X syndrome (FXS), the <jats:italic>Fmr1<\/jats:italic><jats:sup><jats:italic>tm1Cgr<\/jats:italic><\/jats:sup> or <jats:italic>Fmr1<\/jats:italic> \u201cknockout\u201d (KO) mouse. Male KO mice and wild\u2010type littermate controls were tested on learning set and reversal learning tasks. The KO mice were not impaired in associative learning, transfer of learning, or reversal learning, based on measures of learning rate. Analyses of videotapes of the reversal learning task revealed that both groups of mice exhibited higher levels of activity and wall\u2010climbing during the initial sessions of the task than during the final sessions, a pattern also seen for trials following an error relative to those following a correct response. Notably, the increase in both behavioral measures seen early in the task was significantly more pronounced for the KO mice than for controls, as was the error\u2010induced increase in activity level. This pattern of effects suggests that the KO mice reacted more strongly than controls to the reversal of contingencies and pronounced drop in reinforcement rate, and to errors in general. This pattern of effects is consistent with the heightened emotional reactivity frequently described for humans with FXS. \u00a9 2008 Wiley Periodicals, Inc. Dev Psychobiol 50: 473\u2013485, 2008.<\/jats:p>","DOI":"10.1002\/dev.20308","type":"journal-article","created":{"date-parts":[[2008,6,12]],"date-time":"2008-06-12T14:50:26Z","timestamp":1213282226000},"page":"473-485","source":"Crossref","is-referenced-by-count":13,"title":["A mouse model of fragile X syndrome exhibits heightened arousal and\/or emotion following errors or reversal of contingencies"],"prefix":"10.1002","volume":"50","author":[{"given":"J.","family":"Moon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.T.","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.L.","family":"Driscoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.A.","family":"Levitsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.J.","family":"Strupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,12]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"23","article-title":"Fmr1 knockout mice: A model to study fragile x mental retardation","volume":"78","author":"Bakker C.","year":"1994","journal-title":"Cell"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172128"},{"issue":"5","key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1542\/peds.95.5.744","article-title":"Specification of the neurobehavioral phenotype in males with fragile X syndrome","volume":"95","author":"Baumgardner T. L.","year":"1995","journal-title":"Pediatrics"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2005.00135.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.04.009"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892900561959"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1990.tb03516.x"},{"key":"e_1_2_1_9_1","first-page":"265","volume-title":"Learning and cognition in the mentally retarded","author":"Campione J.","year":"1984"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0160-2896(85)90017-0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320400222"},{"issue":"5","key":"e_1_2_1_12_1","first-page":"436","article-title":"Social gaze, social avoidance, and repetitive behavior in fragile X males: A controlled study","volume":"92","author":"Cohen I. L.","year":"1998","journal-title":"American Journal of Mental Retardation"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892901564126"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2004.02.017"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20003"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2004.t01-1-00297.x"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00224-2"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/380069a0"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00292-X"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.118.6.1196"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990528)84:3<277::AID-AJMG22>3.0.CO;2-W"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001432"},{"issue":"1","key":"e_1_2_1_23_1","first-page":"34","article-title":"Neuropathologic findings associated with seizures in FVB mice","volume":"48","author":"Goelz M. F.","year":"1998","journal-title":"Laboratory Animal Science"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02731116"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X1998000100003"},{"key":"e_1_2_1_26_1","first-page":"3","volume-title":"Fragile X syndrome: Diagnosis, treatment, and research","author":"Hagerman R. J.","year":"1996"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.56021\/9780801868436","volume-title":"Fragile X syndrome: Diagnosis, treatment and research","author":"Hagerman R.","year":"2002"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-0025.1989.tb01641.x"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10067"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0193-36"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00701.x"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(97)00155-X"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1352\/0895-8017(2000)105<0286:EBSOPP>2.0.CO;2"},{"issue":"4","key":"e_1_2_1_34_1","first-page":"455","article-title":"Autistic features, personality, and adaptive behavior in males with the fragile X syndrome and no autism","volume":"98","author":"Kerby D. S.","year":"1994","journal-title":"American Journal of Mental Retardation"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1139\/o99-035"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960809)64:2<241::AID-AJMG1>3.0.CO;2-X"},{"issue":"5","key":"e_1_2_1_37_1","first-page":"567","article-title":"Aberrant behaviors of young boys with fragile X syndrome","volume":"98","author":"Lachiewicz A. M.","year":"1994","journal-title":"American Journal of Mental Retardation"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00442299"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-199310000-00007"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.01.038"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.122.2.293"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0304544101"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990402)83:4<268::AID-AJMG7>3.0.CO;2-K"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10005"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.120.6.1367"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(00)00036-1"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb00824.x"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(01)00621-6"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03309-1"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.25.112701.142909"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00285-7"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.8.1145"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.19.8322"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320430106"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.009"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200112000-00008"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20007"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2779(1996)2:4<216::AID-MRDD5>3.0.CO;2-O"},{"key":"e_1_2_1_59_1","first-page":"149","volume-title":"Advances in infancy research","author":"Strupp B. J.","year":"1990"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420230302"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(94)90011-6"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1162\/089892902317236812"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3148.1998.tb00060.x"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(00)00296-5"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90397-H"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/01688639408402641"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(01)00212-3"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2004.00087.x"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2005.06.004"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(99)00003-9"}],"container-title":["Developmental Psychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdev.20308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dev.20308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T10:05:08Z","timestamp":1699956308000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dev.20308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,12]]},"references-count":69,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/dev.20308"],"URL":"https:\/\/doi.org\/10.1002\/dev.20308","archive":["Portico"],"relation":{},"ISSN":["0012-1630","1098-2302"],"issn-type":[{"value":"0012-1630","type":"print"},{"value":"1098-2302","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,12]]}}}