{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:11:56Z","timestamp":1790903516536,"version":"4.1.0"},"reference-count":90,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,23]],"date-time":"2009-02-23T00:00:00Z","timestamp":1235347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The brainstem hypothesis is one of the leading hypotheses concerning the sudden infant death syndrome (SIDS). It states that SIDS, or an important subset of SIDS, is due to abnormal brainstem mechanisms in the control of respiration, chemosensitivity, autonomic regulation, and\/or arousal which impairs the infant's response to life\u2010threatening, but often occurring, stressors during sleep (e.g., hypoxia, hypercarbia, asphyxia, hyperthermia) and leads to sudden death in a vulnerable developmental period. In this review, we summarize neuropathologic evidence from SIDS cases that support this hypothesis, beginning with the seminal report of subtle brainstem gliosis three decades ago. We focus upon recent neurochemical studies in our laboratory concerning the neurotransmitter serotonin (5\u2010HT) and its key role in mediating protective responses to homeostatic stressors via medullary circuits. The possible fetal origin of brainstem defects in SIDS is reviewed, including evidence for adverse effects of prenatal exposure to maternal cigarette smoking and alcohol upon the postnatal development of human brainstem 5\u2010HT pathways. \u00a9 2009 Wiley Periodicals, Inc. Dev Psychobiol 51: 223\u2013233, 2009<\/jats:p>","DOI":"10.1002\/dev.20367","type":"journal-article","created":{"date-parts":[[2009,2,23]],"date-time":"2009-02-23T14:13:02Z","timestamp":1235398382000},"page":"223-233","source":"Crossref","is-referenced-by-count":106,"title":["Brainstem mechanisms underlying the sudden infant death syndrome: Evidence from human pathologic studies"],"prefix":"10.1002","volume":"51","author":[{"given":"Hannah C.","family":"Kinney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10259"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00010-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-003-0757-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00088-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-12-04646.2000"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn848"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00655.2007"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.1.30"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.82.3.253"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.037481"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1770-05.2005"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.09.054"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02593-9"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1991.tb00578.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.02.065"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00093.x"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902930308"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199207000-00002"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000244052"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70324-0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2003.00340.x"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.6.1112"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.78.3.F189"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02294-6"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990205)88:1<83::AID-AJMG15>3.0.CO;2-0"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200103000-00015"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20253"},{"key":"e_1_2_1_29_1","first-page":"31","volume-title":"Sudden infant death syndrome: Problems, progress, and possibilities","author":"Hauck F.","year":"2001"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019725"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00816.2006"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.114475"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.21.2717"},{"issue":"5","key":"e_1_2_1_34_1","first-page":"473","article-title":"The role of brain serotonin. 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