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While previous near\u2010infrared spectroscopy (NIRS) studies in awake infants have demonstrated cortical activations in response to meaningful\/attractive visual stimuli, functional magnetic resonance imaging (fMRI) studies performed on sleeping infants showed negative blood oxygenation level\u2010dependent (BOLD) responses to high\u2010luminance unpatterned stimulations, such as a photic stimulation. To examine the effect of the characteristics of visual stimuli on cortical processing in awake infants, we measured cortical hemodynamic responses in 6\u2010month\u2010old infants during the presentation of a high\u2010luminance unpatterned stimulus by using a NIRS system with 94 measurement channels. Results from 35 infants showed dissociated cortical responses between the occipital region and the other parts of the cortex, including the temporal and prefrontal regions. Although the visual stimulus produced sustained increases in oxygenated hemoglobin (oxy\u2010Hb) signals in the temporal and prefrontal regions, it produced a transient increase in oxy\u2010Hb signals followed by a salient decrease in oxy\u2010Hb signals during a trial in a focal region of the occipital visual region. This suggests that the deactivation of the occipital visual region in response to visual stimulation is not a phenomenon that occurs only in the sleeping state, but that a high\u2010luminance unpatterned stimulus can induce deactivation even in the awake infants. \u00a9 2011 Wiley Periodicals, Inc. 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