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Moreover, on PND10 DER training leads to increased corticosterone levels and activation of the amygdala. In adulthood, male DER animals show better mnemonic abilities in the Morris water maze while the RER exhibit enhanced fear memory. Furthermore, DER animals have a hypofunctioning serotonergic system and express depressive\u2010like behavior and increased aggression. However, they have increased hippocampal glucocorticoid receptors, indicative of efficient hypothalamic\u2013pituitary\u2013adrenal axis function, and an adaptive pattern of stress\u2010induced corticosterone response. The DER experience with its relatively negative emotional valence results in a complex behavioral phenotype, which cannot be considered simply as adaptive or maladaptive. \u00a9 2014<jats:italic>Wiley Periodicals, Inc<\/jats:italic>. Dev Psychobiol 56: 1651\u20131660, 2014.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dev.21248","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T16:03:12Z","timestamp":1410969792000},"page":"1651-1660","source":"Crossref","is-referenced-by-count":10,"title":["A novel model of early experiences involving neonatal learning of a T\u2010maze using maternal contact as a reward or its denial as an event of mild emotional adversity"],"prefix":"10.1002","volume":"56","author":[{"given":"Antonios","family":"Stamatakis","sequence":"first","affiliation":[{"name":"Biology\u2010Biochemistry Lab School of Health Sciences National and Kapodistrian University of Athens 123 Papadiamantopoulou Str. 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