{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:49:08Z","timestamp":1792100948219,"version":"4.4.0"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Coordination of Improvement of Higher Education Personnel (CAPES)"},{"name":"National Research Council of Brazil (CNPq)"},{"name":"FAPERGS-PRONEX","award":["10\/0018.3"],"award-info":[{"award-number":["10\/0018.3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Neonatal handling is an experimental procedure used to analyze the effects of environmental interventions during early postpartum days (PPD). Long\u2010lasting effects of repeated stress exposure in the neonatal period on the maternal side are poorly studied in this model. The aim of this study was to verify if handling the pups induces enduring effects on dam\u015bstress responses, increasing their risk for depression. Dams were divided into two groups (NH\u2010Non\u2010handled and H\u2010Handled) based on the handling procedure (pups were handled for 1\u2009min\/per day from PPD1\u2013PPD10) and then subdivided into four groups (NH, NH\u2009+\u2009S, H, and H\u2009+\u2009S) based on the exposure or not to restraint stress after weaning (1\u2009hr\/per day for 7 days, PPD22\u2013PPD28). We analyzed dam\u015bbehavior in the forced swimming test (FST PPD29\u2013PPD30), plasma basal corticosterone and BDNF levels, as well as adrenal weight (PPD31). The results show that handling alters the stress response of dams to acute and chronic stress, as evidenced by dams of the H group having increased immobility in the first day of FST (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), similar to NH\u2009+\u2009S (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Dams of the H and H\u2009+\u2009S groups show decreased levels of corticosterone when compared to NH and NH\u2009+\u2009S groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), but the H\u2009+\u2009S group shows an increased adrenal weight, suggesting an increased sensibility of the maternal organism to the chronic stress applied after weaning (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). We show that handling may induce a long\u2010lasting effect on maternal stress response; these changes in the dam\u015bemotional reactivity increase their susceptibility for the development of psychiatric disorders such as depression. \u00a9 2016 Wiley Periodicals, Inc. Dev Psychobiol 58: 614\u2013622, 2016.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dev.21405","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T01:44:24Z","timestamp":1459302264000},"page":"614-622","source":"Crossref","is-referenced-by-count":3,"title":["Neonatal handling alters maternal emotional response to stress"],"prefix":"10.1002","volume":"58","author":[{"given":"Adolfo R.","family":"Reis","sequence":"first","affiliation":[{"name":"Departamento de Fisiologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul (UFRGS) Sarmento Leite, 500 Porto Alegre, RS CEP 90050\u2010170 Brasil"},{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Neuroci\u00eancias, Universidade Federal do Rio Grande do Sul (UFRGS) Sarmento Leite, 500 Porto Alegre, RS CEP 90050\u2010170 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul (UFRGS) Sarmento Leite, 500 Porto Alegre, RS CEP 90050\u2010170 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e2mela R.","family":"Menegotto","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul (UFRGS) Sarmento Leite, 500 Porto Alegre, RS CEP 90050\u2010170 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia P.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Neuroci\u00eancias, Universidade Federal do Rio Grande do Sul (UFRGS) Sarmento Leite, 500 Porto Alegre, RS CEP 90050\u2010170 Brasil"},{"name":"Departamento de Pediatria, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS) Ramiro Barcelos, 2350 Porto Alegre, RS CEP 90035\u2010003 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo B.","family":"Lucion","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul (UFRGS) Sarmento Leite, 500 Porto Alegre, RS CEP 90050\u2010170 Brasil"},{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Neuroci\u00eancias, Universidade Federal do Rio Grande do Sul (UFRGS) Sarmento Leite, 500 Porto Alegre, RS CEP 90050\u2010170 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)46011-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20137610.2010.02306.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-200109000-00004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(94)E0045-B"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.05.012"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2007.11.004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2014.11.007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2010.02.012"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1988.tb05208.x"},{"issue":"1","key":"e_1_2_6_11_1","first-page":"43","article-title":"Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: The effects of water depth","volume":"73","author":"Detke M. 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