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The present study analyzed behavioral and physiological disruptions caused by relatively brief binge\u2010like exposures (PDs 3, 5, and 7) with an ethanol dose lower (3.0\u2009g\/kg) than those frequently employed to examine teratological effects during this stage in development. At PD 9, pups were exposed to ethanol doses ranging between .0\u20133.0\u2009g\/kg and tested in terms of breathing patterns and thermoregulation. At PDs 11 and 12, ethanol intake was examined. The main findings were as follows: i) pre\u2010exposure to the drug resulted in brief depressions in breathing frequencies and an exacerbated predisposition toward apneic episodes; ii) these effects were not dependent upon thermoregulatory alterations; iii) early ethanol treatment increased initial consumption of the drug which also caused a marked hypothermia that appeared to regulate a subsequent decrement in ethanol consumption; and iv) ethanol exposure retarded overall body growth and even one exposure to the drug (PD 9) was sufficient to reduce brain weights although there were no indications of microcephaly. In conjunction with studies performed during the late gestational period in the rat, the results indicate that relatively brief binge\u2010like episodes during a critical window of brain vulnerability disrupts the respiratory network and exacerbates initial acceptance of the drug. In addition, ethanol treatments were not found to induce tolerance relative to respiratory and thermal disruptions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dev.21466","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T13:06:06Z","timestamp":1471611966000},"page":"48-59","source":"Crossref","is-referenced-by-count":11,"title":["Neonatal experiences with ethanol intoxication modify respiratory and thermoregulatory plasticity and affect subsequent ethanol intake in rats"],"prefix":"10.1002","volume":"59","author":[{"given":"Mar\u00eda Bel\u00e9n","family":"Acevedo","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra INIMEC\u2010CONICET\u2010 Universidad Nacional de C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Fabiola","family":"Macchione","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra INIMEC\u2010CONICET\u2010 Universidad Nacional de C\u00f3rdoba C\u00f3rdoba Argentina"},{"name":"Facultad de Odontolog\u00eda Universidad Nacional de C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florencia","family":"Anunziata","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra INIMEC\u2010CONICET\u2010 Universidad Nacional de C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga Beatriz","family":"Haymal","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra INIMEC\u2010CONICET\u2010 Universidad Nacional de C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Molina","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra INIMEC\u2010CONICET\u2010 Universidad Nacional de C\u00f3rdoba C\u00f3rdoba Argentina"},{"name":"Facultad de Psicolog\u00eda Universidad Nacional de C\u00f3rdoba C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000125354.15808.24"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3181\/0703\u2010mr\u201069"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02307.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735\u20107044.120.3.710"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.alc.0000051021.99641.19"},{"key":"e_1_2_6_7_1","first-page":"86","article-title":"Prenatal alcohol exposure and miscarriage, stillbirth, preterm delivery, and sudden infant death syndrome","volume":"34","author":"Bailey B. 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