{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:25:27Z","timestamp":1788434727408,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T00:00:00Z","timestamp":1472515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 MH 019929"],"award-info":[{"award-number":["T32 MH 019929"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32\u2010084907"],"award-info":[{"award-number":["T32\u2010084907"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Childhood adversity is highly prevalent and linked to lasting psychological and physiological consequences. A potential mechanism for negative health outcomes is altered stress reactivity. While previous research has addressed associations of childhood adversity with stress system reactivity, sympathetic nervous system (SNS) stress reactivity is understudied. We therefore set out here to examining salivary alpha\u2010amylase (sAA) reactivity in relation with childhood adversity. Forty\u2010one healthy adult subjects (<jats:italic>n<\/jats:italic>\u2009=\u200924 male; <jats:italic>n<\/jats:italic>\u2009=\u200917 female) aged 18\u201334 years underwent the Trier Social Stress Test (TSST) and completed the Childhood Trauma Questionnaire (CTQ). Saliva for measurement of sAA was collected at three time points; before the TSST, immediately after, and 10\u2009min post\u2010TSST. We found that those with childhood trauma had a higher overall sAA response to the TSST, as seen in a repeated measures ANOVA (CTQ by time interaction: <jats:italic>F<\/jats:italic>(1.8,71.5)\u2009=\u20096.46, <jats:italic>p\u2009<\/jats:italic>=\u2009.01) and an independent samples <jats:italic>t<\/jats:italic>\u2010test indicating higher sAA baseline to peak response (<jats:italic>t<\/jats:italic>\u2009=\u20093.22, <jats:italic>p\u2009<\/jats:italic>=\u2009.003). There was also a positive correlation between sAA reactivity and the CTQ subscales of childhood physical abuse (<jats:italic>r<\/jats:italic>\u2009=\u2009.46, <jats:italic>p<\/jats:italic>\u2009=\u2009.005) and emotional abuse (<jats:italic>r<\/jats:italic>\u2009=\u2009.37, <jats:italic>p<\/jats:italic>\u2009=\u2009.024). Healthy adults with low\u2010to\u2010moderate childhood adversity had a heightened sAA response immediately following the stressor. Higher SNS reactivity could be a link to negative health outcomes in adults with early adversity. Future research should address whether altered sAA reactivity is predictive of negative health outcomes in those with childhood adversity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dev.21470","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T06:11:00Z","timestamp":1472623860000},"page":"91-98","source":"Crossref","is-referenced-by-count":42,"title":["Increased alpha\u2010amylase response to an acute psychosocial stress challenge in healthy adults with childhood adversity"],"prefix":"10.1002","volume":"59","author":[{"given":"Yuliya I.","family":"Kuras","sequence":"first","affiliation":[{"name":"Department of Psychology and Volen National Center for Complex Systems Brandeis University Waltham Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"McInnis","sequence":"additional","affiliation":[{"name":"Department of Psychology and Volen National Center for Complex Systems Brandeis University Waltham Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam V.","family":"Thoma","sequence":"additional","affiliation":[{"name":"Department of Psychology and Volen National Center for Complex Systems Brandeis University Waltham Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychology and Volen National Center for Complex Systems Brandeis University Waltham Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Hanlin","sequence":"additional","affiliation":[{"name":"Department of Psychology and Volen National Center for Complex Systems Brandeis University Waltham Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Gianferante","sequence":"additional","affiliation":[{"name":"Department of Psychology and Volen National Center for Complex Systems Brandeis University Waltham Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Rohleder","sequence":"additional","affiliation":[{"name":"Department of Psychology and Volen National Center for Complex Systems Brandeis University Waltham Massachusetts"},{"name":"Chair of Health Psychology, Department of Psychology Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.10.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e3182331fa6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.6.1069"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.8.1132"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PSY.0000058376.50240.2D"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2010.12.019"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15298868.2015.1005659"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(01)33022-4"},{"key":"e_1_2_6_10_1","unstructured":"Child and Adolescent Health Initiative. (2011). National Survey of Children's Health. Available online at:http:\/\/www.childhealthdata.org\/"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.1.102803.144029"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136404"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050078"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.10.021"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033\u20102909.130.3.355"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006\u20100461"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.100022"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.51.1.245"},{"key":"e_1_2_6_19_1","first-page":"123","article-title":"Psychoneuroendocrine approaches to the study of emotion as related to stress and coping","volume":"26","author":"Frankenhaeuser M.","year":"1978","journal-title":"Nebraska Symposium on Motivation"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.008"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.5.592"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20494"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000119004"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.10.018"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2639"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146058"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1745691613506907"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1423363112"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956797610370161"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2014.949667"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2011.12.015"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2008.12.004"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1314.033"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10802\u2010010\u20109412\u20103"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011\u20102663"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026\u2010014\u20108548\u20106"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.10.012"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2011.07.003"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2006.06.010"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2012.07.008"},{"key":"e_1_2_6_42_1","unstructured":"U.S. Department of Health and Human Services A. (2007). Washington DC: U.S. Government Printing Office."},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2005.05.012"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1987.tb00324.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.09.008"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.7.609"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.20164"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.3.371"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00463-3"}],"container-title":["Developmental Psychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdev.21470","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdev.21470","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dev.21470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T01:18:23Z","timestamp":1696555103000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dev.21470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,30]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/dev.21470"],"URL":"https:\/\/doi.org\/10.1002\/dev.21470","archive":["Portico"],"relation":{},"ISSN":["0012-1630","1098-2302"],"issn-type":[{"value":"0012-1630","type":"print"},{"value":"1098-2302","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,30]]}}}