{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:40:39Z","timestamp":1761975639007,"version":"3.37.3"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T00:00:00Z","timestamp":1504915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["09\u2010071546"],"award-info":[{"award-number":["09\u2010071546"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R48\u2010A4968"],"award-info":[{"award-number":["R48\u2010A4968"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008218","name":"Gangstedfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008218","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Heightened levels of glucocorticoids in children and adolescents have previously been linked to prolonged changes in the diurnal regulation of the stress\u2010hormone cortisol, a glucocorticoid regulated by the hypothalamic\u2010pituitary\u2010adrenal\u2010axis (HPA\u2010axis). To address this question, we examined the salivary cortisol awakening response (CAR) and daily cortisol output in 36 children and adolescents (25 girls\/11 boys) aged 7\u201316 years previously treated with glucocorticoids for nephrotic syndrome or rheumatic disorder and 36 healthy controls. Patients and controls did not significantly differ in the CAR or diurnal cortisol output; however, sex\u2010dependent group differences were observed. Specifically, female patients had a higher CAR relative to female controls, while male patients had higher daily cortisol levels compared to male controls. Notably, CAR in female patients and daily cortisol levels in male patients showed a positive linear relationship with the mean daily glucocorticoid doses administered during treatment. The observed dose\u2010response associations suggest that glucocorticoid therapy during childhood and adolescence might trigger long\u2010term changes in HPA\u2010axis regulation, which may differ for males and females.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dev.21559","type":"journal-article","created":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T14:02:46Z","timestamp":1504965766000},"page":"1010-1020","source":"Crossref","is-referenced-by-count":3,"title":["Glucocorticoid treatment earlier in childhood and adolescence show dose\u2010response associations with diurnal cortisol levels"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1229-3686","authenticated-orcid":false,"given":"Martin","family":"Vestergaard","sequence":"first","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Psychiatric Research Unit, Region Zealand Psychiatry Region Zealand Slagelse Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara K.","family":"Holm","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Neuropaediatric Unit, Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Uldall","sequence":"additional","affiliation":[{"name":"Neuropaediatric Unit, Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartwig R.","family":"Siebner","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Department of Neurology Copenhagen University Hospital Bispebjerg Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf B.","family":"Paulson","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Neurobiology Research Unit Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"},{"name":"Center for Integrated Molecular Brain Imaging Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William F.C.","family":"Baar\u00e9","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrine S.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Center for Integrated Molecular Brain Imaging Copenhagen Denmark"},{"name":"Department of Technology Metropolitan University College Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.108985"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3257"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2028"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.05.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.12.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2011.05.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1683"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12388"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S62289"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.11.007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12529-009-9053-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.01.017"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14184-0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.06.007"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.07010051"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579411000484"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579414001102"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2008.03.014"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307893110"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.01.014"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579409000054"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2010.04.004"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.09.013"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.05.030"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13010"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01936.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.04.013"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90277-V"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21103"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2639"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.06.071"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2011.07.015"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420520701649471"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08103.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.02.004"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2014.03.002"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(02)00108-7"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60363-8"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.11.010"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.09.016"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2010.10.015"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00103-4"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20607"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20336"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579405050091"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00306302"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10964-016-0591-2"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.10.010"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2011.02.017"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2647"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.07.006"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182260cbe"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.01.011"}],"container-title":["Developmental Psychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdev.21559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dev.21559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T15:52:28Z","timestamp":1695743548000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dev.21559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,9]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/dev.21559"],"URL":"https:\/\/doi.org\/10.1002\/dev.21559","archive":["Portico"],"relation":{},"ISSN":["0012-1630","1098-2302"],"issn-type":[{"type":"print","value":"0012-1630"},{"type":"electronic","value":"1098-2302"}],"subject":[],"published":{"date-parts":[[2017,9,9]]}}}