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In the summer prior to, or fall of, 4th grade, 132 youth (68 girls; 64 boys; M age\u2009=\u20099.46 years) participated in a social challenge task and reported on their depressive symptoms. In the winter of 6th grade, youth completed a semi\u2010structured interview of depression and a self\u2010report measure of approach\u2010avoidance motivations. Analyses revealed two profiles of risk for adolescent depressive symptoms, with some gender differences: (1) excessive disengagement, reflected in HPA underactivation along with low approach motivation or high avoidance motivation; and (2) excessive engagement, reflected in HPA overactivation along with high approach motivation. This research highlights the importance of a multi\u2010system perspective on development, suggesting that the implications of HPA dysregulation for depressive symptoms are contingent on adolescents\u2019 tendencies toward approach versus avoidance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dev.21600","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T09:30:09Z","timestamp":1516267809000},"page":"303-316","source":"Crossref","is-referenced-by-count":4,"title":["An exploratory analysis of the joint contribution of HPA axis activation and motivation to early adolescent depressive symptoms"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6190-3356","authenticated-orcid":false,"given":"Karen D.","family":"Rudolph","sequence":"first","affiliation":[{"name":"University of Illinois, Urbana\u2010Champaign Urbana 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