{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:28:46Z","timestamp":1789417726233,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001475","name":"Nanyang Technological University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001475","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Psychobiology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The oxytocinergic system is highly involved in social bonding and early caregiver\u2013infant interactions. Here, we hypothesize that oxytocin receptor (OXTR) gene genotype and parental bonding history interact in influencing social development. To address this question, we assessed adult males\u2019 arousal (heart rate changes) in response to different distress vocalizations (human female, human infant and bonobo). Region rs53576 of the OXTR gene was genotyped from buccal mucosa cell samples, and a self\u2010report Parental Bonding Instrument was used (which provide information about parental care or parental overprotection). A significant gene\u2013environment interaction between OXTR genotype and parenting style was found to influence participants\u2019 social responsivity to female cry vocalizations. Specifically, a history of appropriate paternal care in participants accentuated the heightened social sensitivity determined by G\/G homozygosity, while higher versus lower paternal overprotection lead to distinct levels of physiological arousal particularly in A carriers individuals. These results add to our understanding of the dynamic interplay between genetic susceptibility and early environmental experience in shaping the development of appropriate social sensitivity in males.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dev.21606","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T16:23:06Z","timestamp":1516638186000},"page":"333-339","source":"Crossref","is-referenced-by-count":24,"title":["Oxytocin receptor gene polymorphisms (rs53576) and early paternal care sensitize males to distressing female vocalizations"],"prefix":"10.1002","volume":"60","author":[{"given":"Anna","family":"Truzzi","sequence":"first","affiliation":[{"name":"Department of Psychology and Cognitive Science University of Trento Trento Italy"},{"name":"Affiliative and Social Behavior Laboratory, Brain Science Institute RIKEN Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie","family":"Poqu\u00e9russe","sequence":"additional","affiliation":[{"name":"Department of Psychology and Cognitive Science University of Trento Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Setoh","sequence":"additional","affiliation":[{"name":"Division of Psychology Psychology Program School of Social Sciences Nanyang Technological University Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Behavior Unit of Basic Medical Sciences Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc H.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Child and Family Research Eunice Kennedy Shriver National Institute of Child Health and Human Development Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9442-0254","authenticated-orcid":false,"given":"Gianluca","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Psychology and Cognitive Science University of Trento Trento Italy"},{"name":"Division of Psychology Psychology Program School of Social Sciences Nanyang Technological University Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011153"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0040351"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsn004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.44"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1997.tb02140.x"},{"key":"e_1_2_7_7_1","volume-title":"Attachment and loss","author":"Bowlby J.","year":"1999"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2008.00702.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32835df4fa"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2011.12.014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-4560.1990.tb01929.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bbr.2016.06.042","article-title":"Genetic predispositions and parental bonding interact to shape adults' physiological responses to social distress","volume":"325","author":"Esposito G.","year":"2016","journal-title":"Behavioural Brain Research"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327957PSPR0602_03"},{"issue":"1","key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000124796","article-title":"Intracerebroventricular oxytocin stimulates maternal behaviour in the sheep","volume":"46","author":"Kendrick K. 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