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Long Evans rat dams were categorized by maternal licking\/grooming (LG) frequency into High\u2010 and Low\u2010LG mothers. Both female and male offspring from Low\u2010LG rats demonstrated a greater sensitivity to ethanol\u2010induced hypnosis in the loss\u2010of\u2010righting\u2010reflex test at ethanol doses of 3.0 and 3.5\u2009g\/kg during late\u2010adolescence (postnatal Day 50) but not at mid\u2010adolescence (postnatal Day 42). However, we found no effect of maternal care on consumption of a 5% ethanol solution in a two\u2010bottle choice test. We further investigated the association between the observed variations in sensitivity to ethanol\u2010induced hypnosis and baseline hormonal levels in males. In male offspring from Low\u2010LG mothers compared to High\u2010LG mothers, baseline plasma corticosterone and progesterone levels were higher. GABA<jats:sub>A<\/jats:sub> \u03b11 and \u03b4 subunit expressions were also higher in the cerebral cortex of Low\u2010LG males but lower in the cerebellar synaptosomal fraction. Early environmental influences on adolescent sensitivity to ethanol\u2010induced hypnosis, consumption, and preference may be mediated by gonadal hormones and possibly through GABAergic functions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dev.21607","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T12:13:18Z","timestamp":1518610398000},"page":"380-394","source":"Crossref","is-referenced-by-count":4,"title":["Maternal care\u2010related differences in males and females rats\u2019 sensitivity to ethanol and the associations between the GABAergic system and steroids in males"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3491-0849","authenticated-orcid":false,"given":"Daniel O.","family":"Popoola","sequence":"first","affiliation":[{"name":"Department of Psychology Center for Developmental and Behavioral Neuroscience Binghamton University Binghamton New York"},{"name":"Developmental Exposure Alcohol Research Center Binghamton University Binghamton New York"},{"name":"Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions Research Institute on Addictions University of Buffalo Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5372-3902","authenticated-orcid":false,"given":"Nicole M.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Psychology Center for Developmental and Behavioral Neuroscience Binghamton University Binghamton New York"},{"name":"Developmental Exposure Alcohol Research Center Binghamton University Binghamton New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2004.12.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1198"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-9-160"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2004.00428.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000075832.83254.81"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2016.04.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.042960"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.049478"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.10.028"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12035"},{"issue":"1","key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuron.2011.12.012","article-title":"Extrasynaptic GABAA receptors: Their function in the CNS and implications for disease","volume":"73","author":"Brickley S. 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